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Product Name CD27 Chinese Name CD27抗体 Alias CD 27; CD27 antigen; CD27 molecule; CD27_HUMAN; CD27L receptor; LPFS2; MGC20393; OTTHUMP00000238557; S152; T cell activation antigen CD27; T cell antivation antigen S152; T-cell activation antigen CD27; T14; TNFRSF 7; TNFRSF7; TNFSF7; Tp 55; Tp55; Tumor necrosis factor receptor superfamily member 7. literatures Specific References (1) | SL2491R has been referenced in 1 publications.[IF=1.396] Xiong Y et al. Functions of T-cell subsets and their related cytokines in the pathological processes of autoimmune encephalomyelitic mice.(2018) Int J Clin Exp Pathol;11(10):4817-4826. FC&IHC ; Mouse.Research Area Tumour immunology Stem cells lymphocyte t-lymphocyte cell factor Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, Rat, (predicted: Human, Dog, Pig, Cow, ) Applications WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 27kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human CD27: 201-260/260 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]
Function:
Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.
Subunit:
Homodimer. Interacts with SIVA1 and TRAF2.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
Found in most T-lymphocytes.
Post-translational modifications:
Phosphorylated.
O-glycosylated with core 1 or possibly core 8 glycans.
Similarity:
Contains 3 TNFR-Cys repeats.
SWISS:
P26842
Gene ID:
939
Database links:Entrez Gene: 939 Human
Entrez Gene: 21940 Mouse
Omim: 186711 Human
SwissProt: P26842 Human
SwissProt: P41272 Mouse
Unigene: 355307 Human
Unigene: 367714 Mouse
Unigene: 134200 Rat
Product Picture Sample:
Lane 1: Lymph node (Mouse) Lysate at 30 ug
Lane 2: Thymus (Rat) Lysate at 40 ug
Lane 3: Spleen (Rat) Lysate at 40 ug
Lane 4: Lymph node (Rat) Lysate at 30 ug
Primary:
Anti-CD27 (SL2491R) at 1/1000 dilution
Anti-beta-Actin (SL0061R) at 1/2000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 50-55 kD
Observed band size: 60 kD
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