Product Name	TNFRSF14
Chinese Name	Tumour坏死因子受体超家族成员14抗体
Alias	HVEM; Tumor necrosis factor receptor superfamily member 14; HveA1; Tumor necrosis factor receptor-like 2; TR21; CD270; Herpesvirus entry mediator A; TNR14_HUMAN. Similar to Tumor necrosis factor ligand superfamily member 14 (CD258 antigen); CD258; CD258 antigen; CD40 like protein precursor; Herpesvirus entry mediator; Herpesvirus entry mediator ligand; HVEA; HVEM L; HVEML; LIGHT; LIGHTR; TNFSF 14; TR2; UNQ329/PRO509.
literatures	Specific References  (1)     |     SL2457R has been referenced in 1 publications. [IF=5.048] Yang Gao. et al. HSV-1 Infection of Epithelial Dendritic Cells Is a Critical Strategy for Interfering with Antiviral Immunity. VIRUSES-BASEL. 2022 May;14(5):1046  WB ;  Mouse.   PubMed:35632787
Research Area	Tumour  Cell biology  immunology  Neurobiology  Signal transduction  Apoptosis
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Dog, Horse, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	27kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TNFRSF14: 51-150/283 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	TNFRSF14 is a type I membrane protein belonging to the TNF receptor superfamily. This receptor mediates herpes virus entry into cells during infection. TNFRSF14 is able to inhibit the proliferation, activation, and cytokine production of T cells. It has an extracellular domain containing several cysteine-rich repeats and a short cytoplasmic region containing a TRAF (TNF receptor-associated factor) interaction domain. The extracellular domain of TNFRSF14 interacts with the herpes simplex virus envelope glycoprotein D. TNFRSF14 binds two cellular ligands: lymphotoxin alpha and LIGHT. LIGHT is a transmembrane protein expressed and shed from the surface of activated T cells, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes. The LIGHT:TNFRSF14 interaction controls immune response functions by cell death induction as well as cell activation. TNFRSF14 is expressed by peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells. Function: Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells. Subunit: Interacts with TRAF2, TRAF3 and TRAF5. Interacts with herpes simplex virus 1 (HHV-1) and herpes simplex virus 1 (HHV-2) envelope glycoprotein D; functions as an entry receptor for these viruses. Subcellular Location: Membrane; Single-pass type I membrane protein Tissue Specificity: Widely expressed, with the highest expression in lung, spleen and thymus. Post-translational modifications: N-glycosylated. Similarity: Contains 3 TNFR-Cys repeats. SWISS: Q92956 Gene ID: 8764 Database links: Entrez Gene: 8764 Human Entrez Gene: 230979 Mouse Omim: 602746 Human SwissProt: Q92956 Human Unigene: 512898 Human Unigene: 215147 Mouse

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