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Product Name TNFSF18 Chinese Name Tumour坏死因子配体超家族成员18抗体 Alias Activation inducible TNF related ligand; Activation-inducible TNF-related ligand; AITR ligand; AITRL; GITR ligand; GITRL; Glucocorticoid induced TNF related ligand; Glucocorticoid induced TNFR related protein ligand; Glucocorticoid-induced TNF-related ligand; hGITRL; MGC138237; TL6; TNF18_HUMAN; TNLG2A; Tumor necrosis factor (ligand) superfamily member 18; Tumor necrosis factor ligand 2A; Tumor necrosis factor ligand superfamily member 18; literatures Specific References (1) | SL2456R has been referenced in 1 publications.[IF=4.407] Yaping Wang. et al. Blockade of GITRL/GITR signaling pathway attenuates house dust mite-induced allergic asthma in mice through inhibition of MAPKs and NF-κB signaling. Mol Immunol. 2021 Sep;137:238 WB ; Mouse.Research Area Tumour Cell biology Neurobiology Signal transduction Apoptosis Growth factors and hormones Immunogen Species Rabbit Clonality Polyclonal React Species Human, Mouse, (predicted: Rat, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 23kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human TNFSF18: 101-199/199 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells. [provided by RefSeq].
Function:
Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B.
Subunit:
Homodimer. Homotrimer.
Subcellular Location:
Cell membrane; Single-pass type II membrane protein.
Tissue Specificity:
Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells.
Similarity:
Belongs to the tumor necrosis factor family.
SWISS:
Q9UNG2
Gene ID:
8995
Database links:Entrez Gene: 8995 Human
Entrez Gene: 240873 Mouse
Omim: 603898 Human
SwissProt: Q9UNG2 Human
SwissProt: Q7TS55 Mouse
Unigene: 248197 Human
Unigene: 276823 Mouse
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