Product Name	CD137
Chinese Name	Tumour坏死因子受体超家族成员9抗体
Alias	Tumor necrosis factor receptor superfamily member 9; TNFRSF9; 4-1BB; 4 1BB; 4 1BB ligand receptor; Homolog of mouse 4 1BB; Receptor protein 4 1BB; T cell antigen 4 1BB homolog; T cell antigen ILA; CDw137; CD 137; CD137 antigen; Induced by lymphocyte activation; ILA; Interleukin activated receptor homolog of mouse Ly63; Ly63; MGC2172; MGC114552; OTTHUMP00000044294; TNR9_HUMAN.
literatures	Specific References  (3)     |     SL2449R has been referenced in 3 publications. [IF=8.38] Daquinag, A. C., et al. "Depletion of white adipocyte progenitors induces beige adipocyte differentiation and suppresses obesity development." Cell Death & Differentiation (2014).  Mouse.   PubMed:25342467 [IF=3.79] Claycombe, Kate J., et al. "Decreased beige adipocyte number and mitochondrial respiration coincide with increased histone methyl transferase (9Ga) and reduced FGF21 gene expression in Sprague Dawley rats fed prenatal low protein and postnatal high fat diets." The Journal of Nutritional Biochemistry (2016).  FCM ;  Rat.   PubMed:27133430 [IF=3.743] Lei W et al. Phthalides, senkyunolide A and ligustilide, show immunomodulatory effect in improvingatherosclerosis, through inhibiting AP-1 and NF-κB expression. Biomed Pharmacother. 2019 Jun 6;117:109074.  WB ;  Mouse.   PubMed:31177061
Research Area	Tumour  Cell biology  immunology  Apoptosis  The cell membrane受体  Natural killer cells  t-lymphocyte
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	25kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CD137: 101-200/255
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	CD137 exists on the cell surface as a monomer with a molecular mass of 30 kDa and as a dimer of 55 kDa. Human and mouse CD137 share 60% amino acid identity. CD137 (4-1BB), a member of the tumour necrosis factor receptor superfamily, is a type I transmembrane glycoprotein expressed on the cell surface of activated splenic T cells and thymocytes. The functions of CD137 in T lymphocytes include regulating activation, proliferation and apoptosis. CD137 and CD28 are costimulatory molecules of T cell activation. Costimulatory molecules are important in initiating anti-tumor immune responses. CD137 plays an important role in regulating T-cell-dependent immune responses. Expression of CD137 correlates negatively with lymphocyte proliferation and positively with the degree of activation-induced cell death caused by mitogen overstimulation. In monocytes, CD137 induces activation, promotes adherence and prolongs survival. Function: Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation. Subunit: Interacts with TRAF1, TRAF2 and TRAF3. Interacts with LRR-repeat protein 1/LRR-1. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Expressed on the surface of activated T-cells. Similarity: Contains 4 TNFR-Cys repeats. SWISS: Q07011 Gene ID: 3604 Database links: Entrez Gene: 3604 Human Omim: 602250 Human SwissProt: Q07011 Human Unigene: 654459 Human CD137属于Tumour坏死因子超家族成员，是可诱导的T细胞共刺激受体，表达于CD4 + 和CD8 + T细胞、活化的Natural killer cells（natural killercell，NK）和树突状细胞,CD137可抑制T细胞增殖，诱发Apoptosis。
Product Picture	Sample: HepG2(Human) Cell Lysate at 30 ug Primary: Anti-CD137 (SL2449R) at 1/500 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 25 kD Observed band size: 39 kD Sample: Lane 1: Mouse Thymus Lysates Lane 2: Mouse Spleen Lysates Lane 2: Mouse Lymph Lysates Primary: Anti-CD137 (SL2449R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 25kDa Observed band size: 42kDa

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