Product Name	MyoD1/Myf3
Chinese Name	肌原调节蛋白抗体
Alias	Myogenic differentiation 1; AI503393; bHLHc1; MD1; MGC156574; MYF3; MYOD; MYOD1; PUM; MYOD1_HUMAN; Class C basic helix-loop-helix protein 1; bHLHc1; Myogenic factor 3; Myf-3.
literatures	Specific References  (17)     |     SL2442R has been referenced in 17 publications. [IF=6.064] Sanghun Park. et al. Effects of Hypoxia on Proliferation and Differentiation in Belgian Blue and Hanwoo Muscle Satellite Cells for the Development of Cultured Meat. BIOMOLECULES. 2022 Jun;12(6):838  IF ;  Bovine.   PubMed:35740963 [IF=5.924] Jing Zhang. et al. LncRNA SMARCD3-OT1 Promotes Muscle Hypertrophy and Fast-Twitch Fiber Transformation via Enhancing SMARCD3X4 Expression. INT J MOL SCI. 2022 Jan;23(9):4510  WB ;  Chicken.   PubMed:35562902 [IF=5.895] Sheng-Zhong Han. et al. miR-455-3p Is Negatively Regulated by Myostatin in Skeletal Muscle and Promotes Myoblast Differentiation. J AGR FOOD CHEM. 2022;70(33):10121–10133  WB ;  Pig, Mouse.   PubMed:35960196 [IF=5.209] Xianglun Zhang. et al. Protective effect of resveratrol against hydrogen peroxide-induced oxidative stress in bovine skeletal muscle cells. Meat Sci. 2022 Mar;185:108724  IF ;  Cattle.   PubMed:34952489 [IF=5.085] Shuang-Yan Chang. et al. miR-320 regulates myogenesis by targeting growth factor receptor-bound protein-2 and ameliorates myotubes atrophy. INT J BIOCHEM CELL B. 2022 Jun;147:106212  WB ;  Mouse.   PubMed:10.1016/j.biocel.2022.106212 [IF=4.873] Siqi Liu. et al. Effects of lycopene on skeletal muscle-fiber type and high-fat diet-induced oxidative stress. J Nutr Biochem. 2021 Jan;87:108523  WB ;  Mouse.   PubMed:33039582 [IF=4.534] Weng S et al. Improvement of muscular atrophy by AAV–SaCas9-mediated myostatin gene editing in aged mice. Cancer Gene Ther. 2020 Dec;27(12):960-975.  WB ;  Mouse.   PubMed:32398787 [IF=3.405] Dawson LE et al. Induction of Myogenic Differentiation Improves Chemosensitivity of Chemoresistant Cells in Soft-Tissue Sarcoma Cell Lines. Sarcoma. 2020 Mar 26;2020:8647981.  FC ;  human.   PubMed:32300280 [IF=3.231] Pengfei Shi. et al. Analysis of Promoter Methylation of the Bovine FOXO1 Gene and Its Effect on Proliferation and Differentiation of Myoblasts. ANIMALS. 2023 Jan;13(2):319  WB ;  Bovine.   PubMed:36670858 [IF=2.884] Jindi Zhao. et al. Mutation c.−379 C>T in DGAT1 affects intramyocellular lipid content by altering MYOD1 binding affinity. ANIM GENET. 2023 Mar;:  IP ;  Pig.   PubMed:36871966 [IF=2.788] Jin, Zhengyun. et al. Esophageal striated muscle hypertrophy and muscle fiber type transformation in MSTN knockout pigs. TRANSGENIC RES. 2022 May;:1-9  WB ;  Pig.   PubMed:35570234 [IF=2.698] Koike, Tatiana E.. et al. Glutamine supplementation improves contractile function of regenerating soleus muscles from rats. J Muscle Res Cell M. 2022 Feb;:1-11  WB ;  Rat.   PubMed:35201551 [IF=2.39] Dai, Yang, et al. "microRNA-128 regulates the proliferation and differentiation of bovine skeletal muscle satellite cells by repressing Sp1." Molecular and Cellular Biochemistry (2016): 1-10.  WB ;  Bovine.   PubMed:26833195 [IF=1.977] Jie Li. et al. MicroRNA-127-3p regulates myoblast proliferation by targeting Sept7. Biotechnol Lett. 2020 Sep;42(9):1633-1644  WB ;  Mouse.   PubMed:32382971 [IF=1.949] Kou YT et al. A transient protective effect of low-level laser irradiation against disuse-induced atrophy of rats. Lasers Med Sci. 2019 Apr 4.  ICF ;  Rat.   PubMed:30949786 [IF=0] Shiratsuchi, Takaki, et al. "Sonic Hedgehog Supplementation Rapidly induces Myogenesis in Human Induced Pluripotent Stem Cells." Journal of St. Marianna University 6.2 (2015): 225-233.  IF(ICC) ;  Human.   PubMed:J.St.MariannaUniv.6,225–233,2015 [IF=0] Gong, Tao, et al. "The Control of Mesenchymal Stem Cell Differentiation Using Dynamically Tunable Surface Microgrooves." Advanced Healthcare Materials (2014).  Rat.   PubMed:24648133
Research Area	immunology  Developmental biology  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse, Rat,  (predicted: Human, Chicken, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	35kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from mouse MyoD1: 51-150/318
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own transcription which may stabilize commitment to myogenesis. [provided by RefSeq, Jul 2008] Function: Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Activates muscle-specific promoters. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins. Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Seems to form active heterodimers with ITF-2. Interacts with SUV39H1 and CDK9. Interacts with DDX5. Subcellular Location: Nucleus. Post-translational modifications: Phosphorylated by CDK9. This phosphorylation promotes its function in muscle differentiation. Acetylated by a complex containing EP300 and PCAF. The acetylation is essential to activate target genes. Conversely, its deacetylation by SIRT1 inhibits its function. Ubiquitinated on the N-terminus; which is required for proteasomal degradation Similarity: Contains 1 bHLH (basic helix-loop-helix) domain. SWISS: P10085 Gene ID: 17927 Database links: Entrez Gene: 374048 Chicken Entrez Gene: 281938 Cow Entrez Gene: 4654 Human Entrez Gene: 17927 Mouse Entrez Gene: 407604 Pig Entrez Gene: 337868 Rat Entrez Gene: 443405 Sheep Omim: 159970 Human SwissProt: P16075 Chicken SwissProt: Q7YS82 Cow SwissProt: P15172 Human SwissProt: P10085 Mouse SwissProt: P49811 Pig SwissProt: Q02346 Rat SwissProt: P29331 Sheep Unigene: 181768 Human Unigene: 1526 Mouse Unigene: 9493 Rat
Product Picture	Sample: Lane 1: Mouse Skeletal muscle Lysates Lane 2: Mouse Tongue Lysates Lane 3: Rat Skeletal muscle Lysates Lane 4: Rat Tongue Lysates Primary: Anti-MyoD1/Myf3 (SL2442R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 35kDa Observed band size: 50kDa

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