Product Name	Integrin alpha 5
Chinese Name	整合素α5（CD49e）抗体
Alias	Alpha 5 beta 1; CD49 antigen-like family member E; CD49e; ECMRVI; Fibronectin Receptor alpha; Fibronectin receptor alpha subunit; Fibronectin receptor, alpha subunit; FNR; FNRA; gpIc/IIa; Integrin alpha 5 (fibronectin receptor alpha); Integrin alpha F; Integrin alpha-5; Integrin alpha-F; Integrin, alpha 5 (fibronectin receptor, alpha polypeptide); ITGA5; Very late Activation Antigen 5; Very Late Activation Protein 5 alpha; Very late activation protein 5, alpha subunit; VLA5; VLA5A; ITA5_HUMAN; Integrin α5.
Research Area	Cell biology  immunology  Signal transduction  Stem cells  Cell adhesion molecule
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	18/110kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Integrin alpha 5 : 981-1049/1049
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq, Jul 2008] Function: CD49e is the integrin alpha 5 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 5 undergoes post translational cleavage in the extracellular domain to yield disulfide linked light and heavy chains that join with beta 1 to form a fibronectin receptor that is known variously: in lymphocytes as very late (activation) antigen 5 (VLA5); in platelets as glycoprotein IcIIa; and in fibroblasts as extracellular matrix receptor 6 (ECMVI). In addition to adhesion, integrins are known to participate in cell surface mediated signalling. Subunit: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5 and NISCH. Interacts with RAB21 and COMP. Interacts with HIV-1 Tat. Subcellular Location: Membrane; Single-pass type I membrane protein. Similarity: Belongs to the integrin alpha chain family. Contains 7 FG-GAP repeats. SWISS: P08648 Gene ID: 3678 Database links: Entrez Gene: 3678 Human Entrez Gene: 16402 Mouse Entrez Gene: 315346 Rat Omim: 135620 Human SwissProt: P08648 Human SwissProt: P11688 Mouse Unigene: 505654 Human Unigene: 16234 Mouse Unigene: 100796 Rat ITG-α5粘附分子整合素α5也是Cell adhesion molecule的超家族成员，广泛分布于细胞表面和Extracellular matrix的glycoprotein,不仅介导细胞与细胞或细胞与基质之间的连接,而且参与细胞间的Signal transduction,细胞的生长移行,Tumour的转移浸润,免疫炎性反应,血管生成等一系列的生理和病理过程。
Product Picture	Sample: Lane 1: NIH/3T3 (Mouse) Cell Lysate at 30 ug Lane 2: A549 (Human) Cell Lysate at 30 ug Lane 3: U87MG (Human) Cell Lysate at 30 ug Lane 4: K562 (Human) Cell Lysate at 30 ug Lane 5: Huvec (Human) Cell Lysate at 30 ug Primary: Anti-Integrin alpha 5 (SL24400R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 140 kD Observed band size: 140 kD

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Totalgoods,subtotals:￥Checkout