Product Name	CKLF
Chinese Name	趋化素样蛋白抗体
Alias	C32; Chemokine-like factor; chemokine-like factor 1; chemokine-like factor 2; chemokine-like factor 3; chemokine-like factor 4; CKLF_HUMAN; CKLF1; CKLF2; CKLF3; CKLF4; CKLFSF2; HSPC224; transmembrane proteolipid; UCK-1; UCK1.
Research Area	Tumour  Cell biology  immunology  Cell differentiation  lymphocyte
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,  (predicted: Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	17kDa
Cellular localization	The cell membrane Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CKLF: 1-100/152
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The product of this gene is a cytokine. Cytokines are small proteins that have an essential role in the immune and inflammatory responses. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. The protein encoded by this gene is a potent chemoattractant for neutrophils, monocytes and lymphocytes. It also can stimulate the proliferation of skeletal muscle cells. This protein may play important roles in inflammation and in the regeneration of skeletal muscle. Alternatively spliced transcript variants encoding different isoforms have been identified. Naturally occurring read-through transcription occurs between this locus and the neighboring locus CMTM1 (CKLF-like MARVEL transmembrane domain containing 1).[provided by RefSeq, Feb 2011] Function: May play an important role in inflammation and regeneration of skeletal muscle. Partly inhibited by interleukin 10. Isoform 1 has chemotactic response in rat monocytes, neutrophils, and lymphocytes. Subcellular Location: Isoform 1: Secreted. Isoform 2: Membrane; Multi-pass membrane protein. Isoform 4: Membrane; Multi-pass membrane protein. Tissue Specificity: Isoform 1, isoform 2, isoform 3 and isoform 4 have highest expression levels in adult spleen, lung, testis, ovary, peripheral blood leukocyte, placenta, pancreas, and in fetal brain, skeletal muscle, thymus and heart. Lower expression levels in adult skeletal muscle, liver, thymus colon, prostate and fetal spleen and liver. Similarity: Belongs to the chemokine-like factor family. Contains 1 MARVEL domain. SWISS: Q9UBR5 Gene ID: 51192 Database links: Entrez Gene: 51192 Human Entrez Gene: 75458 Mouse Entrez Gene: 245978 Rat Omim: 607885 Human SwissProt: Q9UBR5 Human SwissProt: Q9DAS1 Mouse SwissProt: Q9JK79 Rat Unigene: 15159 Human Unigene: 81197 Rat CKLF（趋化素样因子）是人类趋化素样因子超家族CKLFSF（Chemokine-like Factor Super Family，趋化素样因子超家族）中的一员，Chemokine能使细胞发生趋化运动的小分子cell factor。Chemokine结构和功能比较相似,分子量多在10-20kDa之间,对嗜中性粒细胞、lymphocyte、单核细胞等多种细胞有趋化活性。

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