Product Name	SRP68
Chinese Name	信号识别颗粒抗体
Alias	Signal recognition particle 68 kDa; Signal recognition particle subunit SRP68; Signal recognition particle 68 kDa protein; SRP 68; Srp68; SRP68_HUMAN.
Research Area	immunology  Chromatin and nuclear signals  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Rat,  (predicted: Mouse, Chicken, Dog, Cow, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	71kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SRP68: 401-500/627
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function. Function: Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function. Subunit: Signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. Subcellular Location: Cytoplasm. Nucleus, nucleolus. Similarity: Belongs to the SRP68 family. SWISS: Q9UHB9 Gene ID: 6730 Database links: Entrez Gene: 6730 Human Entrez Gene: 217337 Mouse Entrez Gene: 363707 Rat Omim: 604858 Human SwissProt: Q9UHB9 Human SwissProt: Q8BMA6 Mouse Unigene: 514495 Human Unigene: 29655 Mouse Unigene: 68 Rat 信号识别颗粒(Signalrecognitionparticle,SRP)是介导蛋白识别转运其中普遍存在的机制之一,细胞内蛋白质的定向转移是蛋白质质量数量控制体系的一个重要环节,SRP对参与这一过程的功能基因和蛋白,尤其是蛋白的靶向输送机制的研究对揭示细胞的分化、代谢和病变具有重大的理论意义.
Product Picture	Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (SRP68) Polyclonal Antibody, Unconjugated (SL2381R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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