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Product Name CD134 Chinese Name CD134抗体 Alias Tumor necrosis factor receptor superfamily member 4; ACT 35; ACT35; ACT35 antigen; CD 134; CD134 antigen; Lymphoid activation antigene ACT35; OX 40; OX40; OX40 antigen; OX40 cell surface antigen; OX40 homologue; OX40L receptor; TAX transcriptionally activated glycoprotein 1 receptor; TNFRSF 4; TNFRSF4. Immunogen Species Rabbit Clonality Polyclonal React Species Human, Mouse, Applications WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 27kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/1ml immunogen KLH conjugated synthetic peptide derived from human CD134: 61-160/277 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008].
Function:
Receptor for TNFSF4/OX40L/GP34.
Subunit:
Interacts with TRAF2, TRAF3 and TRAF5.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Similarity:
Contains 4 TNFR-Cys repeats.
SWISS:
P43489
Gene ID:
7293
Database links:
Entrez Gene: 7293 HumanOmim: 600315 Human
SwissProt: P43489 Human
Unigene: 129780 Human
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