Product Name	IDO1
Chinese Name	吲哚胺2,3-双加氧酶抗体
Alias	Indoleamine 2, 3-dioxygenase ; 3-dioxygenase; I23O1_HUMAN; IDO 1; IDO; IDO-1; INDO; indolamine 2,3 dioxygenase; Indole 2 3 dioxygenase; indoleamine 2 3 dioxygenase 1; indoleamine 2 3 dioxygenase; Indoleamine 2,3-dioxygenase 1; Indoleamine pyrrole 2 3 dioxygenase; Indoleamine-pyrrole 2; indoleamine-pyrrole 2,3 dioxygenase.
Research Area	Tumour  Cardiovascular  Cell biology  immunology  Signal transduction  The new supersedes the old
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	45kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from mouse IDO1: 251-350/403
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes indoleamine 2,3-dioxygenase (IDO) – a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan. Function: Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen. Similarity: Belongs to the indoleamine 2,3-dioxygenase family. SWISS: P28776 Gene ID: 15930 Database links: Entrez Gene: 3620 Human Entrez Gene: 15930 Mouse Entrez Gene: 66029 Rat Omim: 147435 Human SwissProt: P14902 Human SwissProt: P28776 Mouse SwissProt: Q9ERD9 Rat Unigene: 840 Human Unigene: 392 Mouse Unigene: 64513 Rat
Product Picture	Sample: Lane 1: Mouse Epididymis tissue lysates Lane 2: Human Hela cell lysates Lane 3: Human Molt-4 cell lysates Primary: Anti-IDO (SL23751R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 45 kD Observed band size: 48 kD Sample: Lane 1: Mouse Placenta tissue lysates Lane 2: Mouse Spleen tissue lysates Lane 3: Mouse Lung tissue lysates Lane 4: Rat Lymph node tissue lysates Lane 5: Human Huvec cell lysates Lane 6: Human Hela cell lysates Lane 7: Human A431 cell lysates Primary: Anti-IDO (SL23751R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 45 kD Observed band size: 47 kD

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