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Product Name Ctip2 Chinese Name Blymphocyte白血病/淋巴瘤11B抗体 Alias B cell lymphoma/leukemia 11B; B-cell CLL/Lymphoma 11B; B-cell lymphoma/leukemia 11B; BC11B_HUMAN; BCL-11B; Bcl11B; COUP-TF interacting protein 2; COUP-TF-interacting protein 2; Ctip 2; hRit1; MS1029; Radiation induced tumor suppressor gene 1; Radiation induced tumor suppressor gene 1 protein; Radiation-induced tumor suppressor gene 1 protein; Rit 1; Rit1. Research Area Tumour Cell biology Neurobiology Signal transduction transcriptional regulatory factor lymphocyte b-lymphocyte Zinc finger protein Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Human, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) Applications WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 95kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Ctip2 : 221-320/894 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2013]
Function:
Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. May be a key regulator of both differentiation and survival during thymocyte development. Repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element.
Subunit:
Interacts with TFCOUP1, SIRT1, ARP1 and EAR2
Subcellular Location:
Nucleus.
Tissue Specificity:
Highly expressed in brain and in malignant T-cell lines derived from patients with adult T-cell leukemia/lymphoma.
Similarity:
Contains 6 C2H2-type zinc fingers.
SWISS:
Q9C0K0
Gene ID:
64919
Database links:Entrez Gene: 64919 Human
Entrez Gene: 58208 Mouse
Omim: 606558 Human
SwissProt: Q9C0K0 Human
SwissProt: Q99PV8 Mouse
Unigene: 709690 Human
Unigene: 392694 Mouse
Product Picture Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Ctip2) Polyclonal Antibody, Unconjugated (SL23676R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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