Product Name	Eppin
Chinese Name	附睾蛋白酶抑制蛋白
Alias	SPINLW1; WAP7; WFDC7; Variant; Cancer/testis antigen 71; CT71; Epididymal protease inhibitor; Protease inhibitor WAP7; Serine protease inhibitor-like with Kunitz and WAP domains 1; EPPI_MOUSE; WAPfour-disulfide core domain protein 7.
Research Area	Tumour  Cell biology  immunology  Developmental biology  Growth factors and hormones  transcriptional regulatory factor  Ubiquitin
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Mouse, Rat, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	13kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from mouse Eppin: 23-134/134
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes an epididymal protease inhibitor, which contains both kunitz-type and WAP-type four-disulfide core (WFDC) protease inhibitor consensus sequences. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene is a member of the WFDC gene family and belongs to the telomeric cluster. The protein can inhibit human sperm motility, and polymorphisms in this gene are associated with male infertility. Read-through transcription also exists between this gene and the downstream WFDC6 (WAP four-disulfide core domain 6) gene. [provided by RefSeq]. Function: Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility (By similarity). Subunit: Monomer (By similarity). Homodimer (By similarity). Homomultimers (By similarity). Interacts (via C-terminus) with SEMG1 (via 164-283 AA) (By similarity). Interacts with LTF (By similarity). Found in a complex with LTF, CLU, EPPIN and SEMG1 (By similarity). Subcellular Location: Secreted. Cell surface. Note=Present on the surface of spermatozoa both before and after capacitation. Tissue Specificity: Expressed in differentiated spermatogonia in testis. Expressed in spermatogonia cell lines GC-1 spg and GC-2spd(ts) as well as in the Leydig tumor cell line MLTC-1 (at protein level). Expressed specifically in epididymis and testis. Expressed predominantly on the postacrosomal region of mouse spermatozoa, in Sertoli cells, Leydig cells, and round spermatids in the testis, and in the principal cells of the cauda epididymidis epithelium. Similarity: Contains 1 BPTI/Kunitz inhibitor domain. Contains 1 WAP domain. SWISS: Q9DA01 Gene ID: 75526 Database links: Entrez Gene: 57119 Human Entrez Gene: 75526 Mouse Entrez Gene: 685161 Rat Omim: 609031 Human SwissProt: O95925 Human SwissProt: Q9DA01 Mouse SwissProt: D4A2Z2 Rat Unigene: 121084 Human 附睾蛋白酶抑制蛋白(Eppin)是一种睾丸/附睾特异性蛋白,可能与精子在附睾的成熟密切相关.

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