Product Name	LXR alpha
Chinese Name	肝脏X受体抗体
Alias	Liver X receptor alpha; LXR a; LXRa; LXRA; NR1H3; NR1H3_HUMAN; Nuclear orphan receptor LXR alpha; Nuclear receptor subfamily 1 group H member 3; Oxysterols receptor LXR alpha; Oxysterols receptor LXR-alpha; RLD 1; RLD1.
literatures	Specific References  (2)     |     SL2342R has been referenced in 2 publications. [IF=6.025] Yue-Qiang Huang. et al. Di-2-ethylhexyl phthalate (DEHP) induced lipid metabolism disorder in liver via activating the LXR/SREBP-1c/PPARα/γ and NF-κB signaling pathway. FOOD CHEM TOXICOL. 2022 Jul;165:113119  WB ;  Bird.   PubMed:35537648 [IF=2.65] Huiming Hu. et al. The Hypolipidemic Effect of Hawthorn Leaf Flavonoids through Modulating Lipid Metabolism and Gut Microbiota in Hyperlipidemic Rats.. EVID-BASED COMPL ALT. 2022 Nov;2022:3033311-3033311  WB ;  Rat.   PubMed:36425260
Research Area	Cell biology  immunology  Bacteria and viruses
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Chicken, Dog, Cow, Horse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	49kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human LXR alpha: 351-447/447
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008]. Function: Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Subunit: Heterodimer of LXRA and RXR. Subcellular Location: Nucleus (Potential). Tissue Specificity: Visceral organs specific expression. Strong expression was found in liver, kidney and intestine followed by spleen and to a lesser extent the adrenals. Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. SWISS: Q13133 Gene ID: 10062 Database links: Entrez Gene: 10062 Human Entrez Gene: 22259 Mouse Entrez Gene: 58852 Rat Omim: 602423 Human SwissProt: Q13133 Human SwissProt: Q9Z0Y9 Mouse SwissProt: Q62685 Rat Unigene: 438863 Human Unigene: 22690 Mouse Unigene: 11209 Rat 肝脏X受体LXRa(Liver X Receptor a)属孤核受体家族,是一种与脂类代谢有关的核受体,该蛋白具有调节脂类的吸收、运输、转化和生物合成的功能，并且在在糖类的代谢等方面也有重要的调控作用。
Product Picture	Sample: Liver (Mouse) Lysate at 40 ug Primary: Anti-LXR alpha (SL2342R) at 1/300 dilution Secondary: HRP conjugated Goat-Anti-rabbit IgG (SL0295G-HRP) at 1/5000 dilution Predicted band size: 49 kD Observed band size: 52 kD Sample: Kidney (Mouse) Lysate at 40 ug Primary: Anti-LXR alpha (SL2342R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 49 kD Observed band size: 48 kD

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