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Product Name AKAP14 Chinese Name A激酶锚定蛋白14抗体 Alias A kinase (PRKA) anchor protein 14; A kinase anchor protein 14; PRKA14; AKAP-14; AKA14_RAT; Protein kinase A-anchoring protein 14; Protein kinase A anchoring protein 14. TAKAP-1.2; Testis-specific A-kinase-anchoring protein TAKAP-80. Research Area Signal transduction Kinases and Phosphatases Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Rat, ) Applications WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 55kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from rat AKAP14: 81-180/502 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a member of A-kinase anchoring proteins (AKAPs), a family of functionally related proteins that target protein kinase A to discrete locations within the cell. The human ortholog of this gene has been characterized. It is reported to be enriched in airway cilia and to regulate ciliary beat frequency by anchoring the protein kinase A holoenzyme near substrates in the axoneme. [provided by RefSeq, May 2013].
Function:
Binds to type II regulatory subunits of protein kinase A and anchors/targets them.
Subunit:
Binds to type II regulatory subunits (RII).
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Present in cilia (at protein level). Expressed in tissues containing axoneme-based organelles (cilia and/or flagella): trachea and testis. Highly expressed in airway cilia.
SWISS:
O35817
Gene ID:
60332
Database links:Entrez Gene: 434756 Mouse
Unigene: 471848 Mouse
Unigene: 42933 Rat
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