Product Name	ABCA1
Chinese Name	腺苷三磷酸结合盒转运体A1抗体
Alias	ABC1; ATP binding cassette transporter A1; ABC 1; ABC Transporter 1; ABCA 1; ATP binding Cassette 1; ATP binding cassette sub family A ABC1 member 1; ATP binding cassette sub family A member 1; ATP binding cassette sub-family A member 1; ATP binding Cassette Transporter 1; ATP-binding Cassette 1; ATP-binding Cassette Transporter 1; CERP; Cholesterol Efflux Regulatory Protein; FLJ14958; HDLDT1; Membrane bound; MGC164864; MGC165011; TD; TGD; ABCA1_HUMAN.
literatures	Specific References  (4)     |     SL23418R has been referenced in 4 publications. [IF=10.041] Peidong You. et al. Targeting and promoting atherosclerosis regression using hybrid membrane coated nanomaterials via alleviated inflammation and enhanced autophagy. Appl Mater Today. 2022 Mar;26:101386  WB ;  Mouse.   PubMed:10.1016/j.apmt.2022.101386 [IF=9.776] Hongyan Zhou. et al. Artemisinin and Procyanidins loaded multifunctional nanocomplexes alleviate atherosclerosis via simultaneously modulating lipid influx and cholesterol efflux. J Control Release. 2022 Jan;341:828  IHC ;  Mouse.   PubMed:34942304 [IF=9.417] Chao-ping He. et al. Construction of nicotinic acid curcumin nanoparticles and its Anti-atherosclerosis effect via PCSK9/LDL-R, ABCA1/Caveolin-1/LXR pathway. MATER DESIGN. 2023 May;229:111931  IHC ;  Mouse.   PubMed:10.1016/j.matdes.2023.111931 [IF=9.273] Ruinan Wu. et al. Mimicking natural cholesterol assimilation to elevate the oral delivery of liraglutide for type Ⅱ diabetes therapy. ASIAN J PHARM SCI. 2022 Sep;:  IF ;  Human.   PubMed:10.1016/j.ajps.2022.08.002
Research Area	immunology  Signal transduction  transcriptional regulatory factor  Transporter
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Pig, Cow, Horse, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	254kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ABCA1: 1551-1650/2261 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in both alleles of this gene cause Tangier disease and familial high-density lipoprotein (HDL) deficiency. [provided by RefSeq, Sep 2019] Function: cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport. Subunit: Interacts with MEGF10. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Widely expressed in adult tissues. Highest levels are found in pregnant uterus and uterus. Post-translational modifications: Phosphorylation on Ser-2054 regulates phospholipid efflux. Palmitoylation by DHHC8 is essential for membrane localization. DISEASE: Defects in ABCA1 are a cause of high density lipoprotein deficiency type 1 (HDLD1) [MIM:205400]; also known as analphalipoproteinemia or Tangier disease (TGD). HDLD1 is a recessive disorder characterized by absence of high density lipoprotein (HDL) cholesterol from plasma, accumulation of cholesteryl esters, premature coronary artery disease (CAD), hepatosplenomegaly, recurrent peripheral neuropathy and progressive muscle wasting and weakness. Defects in ABCA1 are a cause of high density lipoprotein deficiency type 2 (HDLD2) [MIM:604091]; also known as familial hypoalphalipoproteinemia (FHA). HDLD2 is inherited as autosomal dominant trait. It is characterized by moderately low HDL cholesterol, predilection toward premature coronary artery disease (CAD) and a reduction in cellular cholesterol efflux. Similarity: Belongs to the ABC transporter superfamily. ABCA family. SWISS: O95477 Gene ID: 19 Database links: Entrez Gene: 19 Human Entrez Gene: 11303 Mouse Entrez Gene: 313210 Rat Omim: 600046 Human SwissProt: O95477 Human SwissProt: P41233 Mouse Unigene: 429294 Human Unigene: 277376 Mouse Unigene: 148916 Rat
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Human brain glioma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (ABCA1) Polyclonal Antibody, Unconjugated (SL23418R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructions and DAB staining.

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