Product Name	Wnt3a
Chinese Name	信号通路Wnt3a抗体
Alias	MGC119418; MGC119419; MGC119420; Protein Wnt 3a Precursor; Protein Wnt-3a; Wingless type MMTV integration site family member 3A; Wnt 3a; WNT3A protein.
literatures	Specific References  (3)     |     SL23278R has been referenced in 3 publications. [IF=5.895] Yu-Sheng Shi. et al. Pteris laeta Wall. and Its New Phytochemical, Pterosinsade A, Promote Hippocampal Neurogenesis via Activating the Wnt Signaling Pathway. J AGR FOOD CHEM. 2023;XXXX(XXX):XXX-XXX  WB ;  Murine.   PubMed:36892329 [IF=2.534] EnShuang Xu. et al. Establishment and transcriptome characterization of tamoxifen-resistant canine mammary gland tumor cells. Res Vet Sci. 2022 Feb;:  WB ;  Dog.   PubMed:35193047 [IF=0] Liyi Huang. et al. Enhanced effect of combining bone marrow mesenchymal stem cells (BMMSCs) and pulsed electromagnetic fields (PEMF) to promote recovery after spinal cord injury in mice. MedComm. 2022 Aug;3(3):e160  WB ;  Mouse.   PubMed:35949547
Research Area	Cell biology  Neurobiology  Stem cells  Cell differentiation
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, Dog, Pig, Cow, Rabbit, Sheep, )
Applications	WB=1:500-2000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	37kDa
Cellular localization	Extracellular matrix Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Wnt3a: 135-230/352
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region. [provided by RefSeq, Jul 2008] Function: Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube. Subunit: Interacts with PORCN. Interacts with APCDD1 and WLS. Component of the Wnt-Fzd-LRP5-LRP6 signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts directly in the complex with LRP6. Subcellular Location: Secreted, extracellular space, extracellular matr Tissue Specificity: Moderately expressed in placenta and at low levels in adult lung, spleen, and prostate. Post-translational modifications: Palmitoylation at Ser-209 by PORCN is required for proper trafficking to cell surface, vacuolar acidification is critical to release palmitoylated WNT3A from WLS in secretory vesicles. Similarity: Belongs to the Wnt family. SWISS: P56704 Gene ID: 89780 Database links: Entrez Gene: 89780 Human Entrez Gene: 22416 Mouse Entrez Gene: 303181 Rat Omim: 606359 Human SwissProt: P56704 Human SwissProt: P27467 Mouse Unigene: 336930 Human Unigene: 1367 Mouse Unigene: 130971 Rat Wnt3a是Wnt家族的成员之一,对神经Stem cells的增殖及分化有一定的调控作用,Wnt3a蛋白可以促进神经Stem cells向神经元分化.
Product Picture	Sample: Lane 1: Cerebrum (Rat) Lysate at 40 ug Lane 2: Stomach (Rat) Lysate at 40 ug Primary: Anti-Wnt3a (SL23278R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 39 kD Observed band size: 39 kD

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