TEL: +86 571 56623320 EMAIL: [email protected]
Product Name C Peptide (mouse) Chinese Name 小鼠C-肽抗体 Alias proinsulin precursor; Hyperproinsulinemia; INS; Insulin Precursor; IRDN; Proinsulin; Propeptide; C-Peptide; INS2_MOUSE. Research Area Tumour Cell biology Signal transduction Growth factors and hormones Diabetes cell factor Immunogen Species Rabbit Clonality Polyclonal React Species Rat, (predicted: Mouse, ) Applications IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 3kDa Cellular localization Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from mouse C Peptide: 57-87/110 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail C Peptide is part of the molecule of Proinsulin, that consists of three parts: C Peptide and two long strands of amino acids (called the alpha and beta chains) that later become linked together to form the insulin molecule. From every molecule of proinsulin, one molecule of insulin plus one molecule of C Peptide are produced. C peptide is released into the blood stream in equal amounts to insulin. A test of C peptide levels will show how much insulin the body is making. Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
Subunit:
Heterodimer of a B chain and an A chain linked by two disulfide bonds.
Subcellular Location:
Secreted.
Similarity:
Belongs to the insulin family.
SWISS:
P01326
Gene ID:
16334
Database links:Entrez Gene: 3630 Human
Entrez Gene: 16334 Mouse
Omim: 176730 Human
SwissProt: P01308 Human
SwissProt: P01326 Mouse
Unigene: 272259 Human
C肽是胰岛β细胞的分泌产物,与大、小鼠有部分交叉,它与胰岛素有一个共同的前体——胰岛素原
C肽是连接肽,因为最初它是连接A、B两条链的中间段,胰岛素原分解后才能独立存在,它也能从细胞释放到血液中。因此,从胰岛细胞分泌入血的主要成分有两种,一种是人们所熟悉的胰岛素,另一种就是C肽。
近年来,随着深入的研究,发现C肽是具有生物学活性的。并且,这种生物学活性对于延缓Diabetes慢性并发症的发生和发展可能具有重要的作用.Product Picture Paraformaldehyde-fixed, paraffin embedded (rat pancreas); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (C Peptide) Polyclonal Antibody, Unconjugated (SL23205R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Scan Wechat Qrcode