Product Name	CX3CL1
Chinese Name	CX3CL1抗体
Alias	C3Xkine; Chemokine C X3 C motif ligand 1; Chemokine CX3C Motif Ligand 1; CX3C membrane anchored chemokine; CXC 3; CXC3; CXC3C; FKN; Fractalkine; Neurotactin; NTN; NTT; SCYD 1; SCYD1; Small inducible cytokine D1; Small inducible cytokine subfamily D (Cys X3 Cys) member 1; Small inducible cytokine subfamily D member 1; X3CL1_HUMAN.
Research Area	Cardiovascular  immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	41kDa
Cellular localization	The cell membrane Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CX3CL1: 61-150/397 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	CX3CL1 is a member of the delta chemokine subfamily that contains a unique CX3C cysteine motif near the N-terminal. Unlike other known chemokines, it is a type 1 membrane protein containing a chemokine domain tethered on a long mucin-like stalk. CX3CL1, a leukocyte chemoattractant, is expressed in various tissues including the brain, heart, lung, kidney, skeletal muscle, and testis. The expression is reported to be up-regulated in endothelial cells and microglia by inflammatory signals. CX3CR1, a specific receptor for fractalkine, mediates both leukocyte migration and adhesion. Function: The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1. Subunit: Monomer. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Processed fractalkine: Secreted. Tissue Specificity: Small intestine, colon, testis, prostate, heart, brain, lung, skeletal muscle, kidney and pancreas. Post-translational modifications: A soluble short 95 kDa form may be released by proteolytic cleavage from the long membrane-anchored form. O-glycosylated with core 1 or possibly core 8 glycans. Similarity: Belongs to the intercrine delta family. SWISS: P78423 Gene ID: 6376 Database links: Entrez Gene: 6376 Human Entrez Gene: 20312 Mouse Entrez Gene: 89808 Rat Omim: 601880 Human SwissProt: P78423 Human SwissProt: O35188 Mouse SwissProt: O55145 Rat Unigene: 531668 Human 神经趋化蛋白cx3cl1免疫应答应答及细胞附着，参与cell factor和Chemokine介导Signal transduction、免疫细胞趋化性、调控炎症应答反应、白细胞附着激活、正调控钙非依赖细胞附着。
Product Picture	Sample: Lane 1: Human HepG2 cell lysates Lane 2: Human SH-SY5Y cell lysates Lane 3: Human U251 cell lysates Lane 4: Human A549 cell lysates Lane 5: Human Huvec cell lysates Primary: Anti-CX3CL1 (SL23140R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 41 kD Observed band size: 95 kD

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