Product Name	IL17RA
Chinese Name	白介素17受体抗体
Alias	Interleukin-17 receptor A; IL-17 receptor A; IL-17RA; hIL-17R; IL-17R; MGC10262; CD217; CDw217; IL17 RECEPTOR; IL17FR; AW538159; I17RA_HUMAN.
Research Area	The cell membrane受体  Cell Surface Molecule
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	92kDa
Cellular localization	The cell membrane Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from mouse IL-17R/IL-17RA/CD217: 168-178/864aa <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Interleukin 17A (IL17A)is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. [provided by RefSeq] Function: Receptor for IL17A and IL17F. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Widely expressed. Post-translational modifications: Glycosylated. DISEASE: Defects in IL17RA are the cause of familial candidiasis type 5 (CANDF5) [MIM:613953]. CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. Similarity: Contains 1 SEFIR domain. SWISS: Q60943 Gene ID: 16172 Database links: Entrez Gene: 23765 Human Entrez Gene: 16172 Mouse Omim: 605461 Human SwissProt: Q96F46 Human SwissProt: Q60943 Mouse Unigene: 48353 Human Unigene: 4481 Mouse
Product Picture	Sample: Thymus (Mouse) Lysate at 40 ug Primary: Anti- CD217 (SL23053R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 92 kD Observed band size: 120 kD Sample: SiHa (Human) Cell Lysate at 30 ug Primary: Anti-17R’IL-17RA’CD217 (SL23053R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 120 kD Observed band size: 120 kD

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