Product Name	PAX7
Chinese Name	配对盒基因7抗体
Alias	Paired box gene 7; FLJ37460; HUP1; OTTHUMP00000002534; Paired box 7; Paired box homeotic gene 7; Paired box protein Pax-7; Paired domain gene 7; Paired domain gene HuP1; PAX7 transcriptional factor; PAX7/FKHR fusion gene, included; PAX7B; RGD1564360; PAX7_HUMAN.
literatures	Specific References  (6)     |     SL22741R has been referenced in 6 publications. [IF=11.092] Hanhao Dai. et al. Hierarchically injectable hydrogel sequentially delivers antagomiR-467a-3p-loaded and antagomiR-874-5p-loaded satellite-cell-targeting bioengineered extracellular vesicles attenuating sarcopenia. ADV HEALTHC MATER. 2023 Feb;:2203056  IF ;  Mouse.   PubMed:36782053 [IF=8.025] Siqi Liu. et al. Estrogen-mediated oar-miR-485-5p targets PPP1R13B to regulate myoblast proliferation in sheep. INT J BIOL MACROMOL. 2023 May;236:123987  WB ;  Ewe.   PubMed:36906210 [IF=7] Xu Enbo. et al. Tissue-like cultured fish fillets through a synthetic food pipeline. npj Science of Food. 2023 May;7(1):1-13  ICC ;  Fish.   PubMed:37149658 [IF=4.889] Hanhao Dai. et al. Inhibiting uptake of extracellular vesicles derived from senescent bone marrow mesenchymal stem cells by muscle satellite cells attenuates sarcopenia. J ORTHOP TRANSL. 2022 Jul;35:23  IF ;  Mouse.   PubMed:35846725 [IF=4.534] Weng S et al. Improvement of muscular atrophy by AAV–SaCas9-mediated myostatin gene editing in aged mice. Cancer Gene Ther. 2020 Dec;27(12):960-975.  WB ;  Mouse.   PubMed:32398787 [IF=3.231] Qian Chen. et al. Transcriptomic Analysis Reveals mRNA and Alternative Splicing Events in Ovine Skeletal Muscle Satellite Cells during Proliferation and Differentiation. ANIMALS. 2023 Jan;13(6):1076  ICC ;  Sheep.   PubMed:36978617
Research Area	Signal transduction  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse, Rat,  (predicted: Human, Chicken, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 IHC-P=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	55kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PAX7: 141-240/520
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	PAX7 is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of PAX7 is unknown but it is speculated to be involved in tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Alternative splicing in this gene has produced two known products but the biological significance of the variants is unknown. Function: Probable transcription factor. May have a role in myogenesis. Subunit: Can bind to DNA as a heterodimer with PAX3. Interacts with DAXX. Subcellular Location: Nucleus. DISEASE: Defects in PAX7 are a cause of rhabdomyosarcoma type 2 (RMS2) [MIM:268220]. It is a form of rhabdomyosarcoma, a highly malignant tumor of striated muscle derived from primitive mesenchimal cells and exhibiting differentiation along rhabdomyoblastic lines. Rhabdomyosarcoma is one of the most frequently occurring soft tissue sarcomas and the most common in children. It occurs in four forms: alveolar, pleomorphic, embryonal and botryoidal rhabdomyosarcomas. Note=A chromosomal aberration involving PAX7 is found in rhabdomyosarcoma. Translocation t(1;13)(p36;q14) with FOXO1. The resulting protein is a transcriptional activator. Similarity: Belongs to the paired homeobox family. Contains 1 homeobox DNA-binding domain. Contains 1 paired domain. SWISS: P23759 Gene ID: 5081 Database links: Entrez Gene: 5081 Human Entrez Gene: 18509 Mouse Entrez Gene: 500574 Rat Omim: 167410 Human SwissProt: P23759 Human SwissProt: P47239 Mouse Unigene: 113253 Human Unigene: 218760 Mouse Unigene: 226327 Rat 同源结构域蛋白（Homeodomain Proteins） PAX-7属于转录抑制因子。在胚胎发育和Tumour生长中起关键作用。其突变和某些Tumour的发病有关。
Product Picture	Sample: Uterus(Mouse) Lysate at 40 ug Skeletal muscle(Rat) Lysate at 40 ug Skeletal muscle(Mouse) Lysate at 40 ug Primary: Anti-PAX7 (SL22741R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 56 kD Observed band size: 56 kD Paraformaldehyde-fixed, paraffin embedded (mouse uterus); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PAX7) Polyclonal Antibody, Unconjugated (SL22741R) at 1:2000 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (mouse embryo); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PAX7) Polyclonal Antibody, Unconjugated (SL22741R) at 1:2000 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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