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Product Name Inhibin beta A Chinese Name 抑制素βA/Inhibin βA抗体 Alias Activin A; Activin beta A chain; Activin beta-A chain; ActivinA; EDF; Erythroid differentiation factor; Erythroid differentiation protein; INHBA; INHBA_HUMAN; Inhibin beta A chain. Research Area Cell biology Neurobiology Signal transduction Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, Rat, (predicted: Human, Chicken, Cow, Rabbit, Sheep, ) Applications WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 45kDa Cellular localization Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Inhibin beta A : 351-426/426 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome
Subunit:
Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B. Interacts with FST and FSTL3.
Subcellular Location:
Secreted.
Similarity:
Belongs to the TGF-beta family.
SWISS:
P08476
Gene ID:
3624
Database links:Entrez Gene: 3624 Human
Omim: 147290 Human
SwissProt: P08476 Human
Unigene: 583348 Human
Unigene: 9874 Rat
Product Picture Sample:
Lane 1: Ovary (Mouse) Lysate at 40 ug
Lane 2: Testis (Mouse) Lysate at 40 ug
Lane 3: Placenta (Mouse) Lysate at 40 ug
Lane 4: Adrenal gland (Mouse) Lysate at 40 ug
Lane 5: Pituitary (Mouse) Lysate at 40 ug
Lane 6: Adrenal gland (Rat) Lysate at 40 ug
Lane 7: Pituitary (Rat) Lysate at 40 ug
Primary: Anti-Inhibin beta A (SL22620R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 45 kD
Observed band size: 48 kD
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