Product Name	GABA
Chinese Name	γ氨基丁酸抗体
Alias	gamma-aminobutyric acid; gamma aminobutyric acid; 4 aminobutanoic acid; Gamma amino butyric acid; γ－aminobutyric acid (GABA).
literatures	Specific References  (2)     |     SL2252R has been referenced in 2 publications. [IF=5.25] Li-Min Zhang. et al. Subanesthetic dose of S-ketamine improved cognitive dysfunction via the inhibition of hippocampal astrocytosis in a mouse model of post-stroke chronic stress. J PSYCHIATR RES. 2023 Feb;158:1  IF ;  Mouse.   PubMed:36542981 [IF=1.28] Luo, Li, et al. "Niche astrocytes promote the survival, proliferation and neuronal differentiation of co‑transplanted neural stem cells following ischemic stroke in rats." Experimental and Therapeutic Medicine.  IF(IHC-P) ;  Rat.   PubMed:28352345
Product Type	Small molecule anti
Research Area	immunology  Drugs and Compounds
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	0.1031kDa
Cellular localization	cytoplasmic The cell membrane Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated GABA
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter. GABA acts at inhibitory synapses in the brain and spinal cord. Inhibition is provoked by GABA binding resulting in hyperpolarization of the synaptic transmembrane potential of the affected neuron. GABA binding causes ion channels to open allowing either the flow of chloride or potassium ions into or out of the cell. SWISS: N/A CAS: 56-12-2 γ-氨基丁酸（简称GABA）是一种天然存在的非蛋白质氨基酸，是哺乳动物中枢神经系统中重要的抑制性神经传达物质，约50%的中枢神经突触部位以GABA为递质。在人体大脑皮质、海马、丘脑、基底神经节和小脑中起重要作用，并对机体的多种功能具有调节作用。当人体内GABA缺乏时，会产生焦虑、不安、疲倦、忧虑等情绪，一般长久处于高压力族群如身处竞争环境中的人群、运动员、上班族等，都很容易缺乏GABA需要及时补充以便舒缓情绪。
Product Picture	Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (GABA) Polyclonal Antibody, Unconjugated (SL2252R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-GABA Polyclonal Antibody, Unconjugated(SL2252R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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