Product Name	Haspin
Chinese Name	丝氨酸/苏氨酸蛋白激酶蛋白抗体
Alias	germ cell associated 2; Germ cell-specific gene 2 protein; GSG2; H-Haspin; Haploid germ cell-specific nuclear protein kinase; HASP_HUMAN; Serine/threonine-protein kinase Haspin.
literatures	Specific References  (3)     |     SL22470R has been referenced in 3 publications. [IF=3.329] Zhu D et al. HASPIN is involved in the progression of gallbladder carcinoma. Exp Cell Res. 2020 Jan 24:111863.  IHC-P ;  Human.   PubMed:31987787 [IF=3.329] Han X et al. Haspin knockdown can inhibit progression and development of pancreatic cancer in vitro and vivo. Exp Cell Res. 2019 Sep 4:111605.  IHC-P ;  Human.   PubMed:31493385 [IF=3.322] Luhao Li. et al. GSG2 promotes tumor growth through regulating cell proliferation in hepatocellular carcinoma. BIOCHEM BIOPH RES CO. 2022 Oct;625:109  IHC ;  Human.   PubMed:35952607
Research Area	Chromatin and nuclear signals  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse, Rat,  (predicted: Human, )
Applications	WB=1:500-2000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	88kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from mouse Haspin: 421-520/754
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Haspins is a protein family containing a distinctive C-terminal kinase domain and a divergent N-terminus. Haspin homologues occur within a diverse group of eukaryotes, including animals, plants and fungi, which suggests an early evolutionary origin. Haspin, a nuclear protein strongly expressed in male germ cells, is responsible for the phosphorylation of histone H3 at Thr-3. Depletion of Haspin RNA prevents normal alignment of chromosomes at metaphase, suggesting a crucial role for haspin during chromosome segregation. Expression of haspin also occurs in adult thymus and bone marrow, with weaker expression in adult prostate, intestine, lung, spleen, and lymph node. The gene encoding human haspin maps to chromosome 17p13. Function: Serine/threonine-protein kinase that phosphorylates histone H3 at 'Ser-3' (H3T3ph) during mitosis. This positions and activates AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. Subcellular Location: Nucleus. Chromosome. Cytoplasm, cytoskeleton, spindle. Note=Nuclear during interphase and associates with the chromosomes and spindle apparatus during mitosis. Tissue Specificity: Strongly expressed in testis. Also present in thymus and bone marrow and low levels observed in prostate, intestine, lung, spleen and lymph node. Expressed in fetal skin, liver, kidney and small intestine and also in proliferating but not non-proliferating cell lines. Post-translational modifications: Autophosphorylated on both serine and threonine residues (By similarity). Strongly phosphorylated during mitosis but this does not appear to significantly affect its intrinsic kinase activity. Phosphorylation by AURKB is required for full activity toward histone H3 at 'Ser-3' in mitosis. Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Haspin subfamily. Contains 1 protein kinase domain. SWISS: Q9Z0R0 Gene ID: 14841 Database links: Entrez Gene: 83903 Human Omim: 609240 Human SwissProt: Q8TF76 Human Unigene: 534059 Human
Product Picture	Sample: Thymus(Rat) Lysate at 40 ug Kidney(Rat) Lysate at 40 ug Kidney(Mouse) Lysate at 40 ug Primary: Anti-Haspin (SL22470R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 90 kD Observed band size: 90 kD

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