Product Name	BMP7
Chinese Name	骨形态发生蛋白7抗体
Alias	bone morphogenetic protein 7 precursor; osteogenic protein 1; BMP-7; OP-1; BMP 7; Bone morphogenic protein 7; Eptotermin alfa; OP 1; OP1; BMP7_HUMAN.
literatures	Specific References  (4)     |     SL2242R has been referenced in 4 publications. [IF=5.959] Wang Y et al. SPARCL1 promotes C2C12 cell differentiation via BMP7-mediated BMP/TGF-β cell signaling pathway. Cell Death Dis. 2019 Nov 7;10(11):852.  WB ;  Mouse.   PubMed:31699966 [IF=5.31] Shuxin Liu. et al. Overexpression of bone morphogenetic protein 7 reduces oligodendrocytes loss and promotes functional recovery after spinal cord injury. 2021 Aug 13  WB ;  Rat.   PubMed:34390115 [IF=3.54] Mai et al. Dyssynchronous pacing triggers endothelial-mesenchymal transition through heterogeneity of mechanical stretch in a canine model. (2014) Circ.. 79:201-9  WB ;  Canine.   PubMed:25373595 [IF=3.309] Gulistan Sanem Saribas. et al. Ellagic acid increases implantation rates with its antifibrotic effect in the rat model of intrauterine adhesion. PATHOL RES PRACT. 2023 Jun;246:154499  IHC ;  Rat.   PubMed:37163881
Research Area	Tumour  Cell biology  immunology  Apoptosis  Growth factors and hormones  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat, Rabbit,  (predicted: Chicken, Dog, Pig, Cow, Horse, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	15.7/47kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human BMP7: 293-350/431
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development and possible bone inductive activity. [provided by RefSeq]. Function: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. Subunit: Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1. Subcellular Location: Secreted. Tissue Specificity: Expressed in the kidney and bladder. Lower levels seen in the brain. Post-translational modifications: Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms (PubMed:17977014). Similarity: Belongs to the TGF-beta family. SWISS: P18075 Gene ID: 655 Database links: Entrez Gene: 477270 Dog Entrez Gene: 655 Human Entrez Gene: 12162 Mouse Entrez Gene: 492315 Pig Entrez Gene: 85272 Rat Omim: 112267 Human SwissProt: P18075 Human SwissProt: P23359 Mouse Unigene: 473163 Human Unigene: 595 Mouse Unigene: 18030 Rat 骨形态发生蛋白7（BMP-7）是转化生长因子β超家族成员,参与器官发生,细胞增殖、分化及凋亡等.
Product Picture	Sample: Bone (Mouse) Lysate at 40 ug Primary: Anti-BMP7 (SL2242R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 15.7/47 kD Observed band size: 47,50kD Sample: Lane 1: Kidney (Mouse) Lysate at 40 ug Lane 2: Placenta (Mouse) Lysate at 40 ug Lane 3: Cerebrum (Mouse) Lysate at 40 ug Lane 4: NIH/3T3 (Mouse) Cell Lysate at 30 ug Lane 5: Cerebrum (Rat) Lysate at 40 ug Primary: Anti-BMP7 (SL2242R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 47 kD Observed band size: 47 kD Sample: 293T Cell (Human) Lysate at 30 ug Primary: Anti-BMP7 (SL2242R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 15.7/47kD Observed band size: 49/40 kD Tissue/cell: rabbit alveolar bone; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-BMP7 Polyclonal Antibody, Unconjugated(SL2242R) 1:600, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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