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Product Name GDNFRA Chinese Name GDNF家族受体α-1抗体 Alias GDNF Receptor alpha 1; GFRa-1; GFR alpha; GDNFR alpha; TmR1; GFR alpha-1; RETL1; RET ligand 1; TGF-beta related neurotrophic factor receptor-1; AU042498; DKFZp313E1012; DKFZp686J0156; FLJ10561; FLJ31546; GDNFR; Gdnfr alpha; GFR-ALPHA-1; GFRA1; GRFA1; LOC143381; MGC23045; Ret; RET1L; RETL1; TRNR1; GFRA1_HUMAN; GDNF family receptor alpha-1; GDNF receptor alpha-1; GDNFR-alpha-1; TGF-beta-related neurotrophic factor receptor 1. TGF-β related neurotrophic factor receptor-1; Research Area immunology Neurobiology Immunogen Species Rabbit Clonality Polyclonal React Species Human, Mouse, Rat, (predicted: Chicken, Dog, Pig, Cow, Rabbit, ) Applications WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 44kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human GDNFRA: 81-180/465 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq]
Function:
Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor.
Subunit:
2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET.
Subcellular Location:
Cell membrane; Lipid-anchor, GPI-anchor.
Similarity:
Belongs to the GDNFR family.
SWISS:
P56159
Gene ID:
2674
Database links:Entrez Gene: 2674 Human
Entrez Gene: 14585 Mouse
Omim: 601496 Human
SwissProt: P56159 Human
SwissProt: P97785 Mouse
Unigene: 591913 Human
Unigene: 88489 Rat
GFRα-1是由68个氨基酸组成的蛋白,广泛表达于中枢神经系统和外周器官。活性亚单位由两个GFRα-1分子中间由二硫键连接而成的复合物。属于GDNFR 家族成员。Product Picture Sample:
MCF-7 (Human) Cell Lysate at 30 ug
U251 (Human) Cell Lysate at 30 ug
Jurkat (Human) Cell Lysate at 30 ug
A549 (Human) Cell Lysate at 30 ug
Cerebrum (Mouse) Lysate at 40 ug
Cerebrum (Rat) Lysate at 40 ug
Testis (Mouse) Lysate at 40 ug
Testis (Rat) Lysate at 40 ug
Small intestine (Mouse) Lysate at 40 ug
Primary: Anti-GDNFRA (SL22346R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 51 kD
Observed band size: 51 kD
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