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Product Name SP-B/Surfactant Protein B Chinese Name 肺表面活性蛋白B抗体 Alias 18 kDa pulmonary surfactant protein; 18 kDa pulmonary-surfactant protein; 6 kDa protein; Pulmonary surfactant apoprotein PSP B; Pulmonary surfactant associated protein B 18kD; Pulmonary surfactant associated protein B; Pulmonary surfactant associated proteolipid SPL Phe; SFTB3; SFTP3; SFTPB; SFTPB surfactant; Surfactant pulmonary associated protein B; Prosurfactant Protein B; pulmonary surfactant-associated glycoprotein B; proSP B; PSP B; PSPB; PSPB_MOUSE; Pulmonary surfactant-associated protein B; Pulmonary surfactant-associated proteolipid SPL(Phe); SFTB3; SFTP3; SFTPB; SP B; SPB. Research Area Tumour Cardiovascular Signal transduction The new supersedes the old Immunogen Species Rabbit Clonality Polyclonal React Species Human, Mouse, Rat, Applications WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 41kDa Cellular localization Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from mouse SP-B: 141-240/377 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.Homodimer; disulfide-linked. Secreted, extracellular space. Function : Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.
Function:
Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.
Subunit:
Homodimer; disulfide-linked.
Subcellular Location:
Secreted, extracellular space, surface film.
Similarity:
Contains 1 saposin A-type domain.
Contains 3 saposin B-type domains.
SWISS:
P07988
Gene ID:
6439
Database links:Entrez Gene: 6439 Human
Entrez Gene: 20388 Mouse
Omim: 178640 Human
SwissProt: P07988 Human
SwissProt: P50405 Mouse
Unigene: 512690 Human
Unigene: 46033 Mouse
肺泡表面活性物质B(SP-B)也属糖Binding protein家族,参与肺泡表面活性膜的形成和代谢,除在Ⅱ型细胞中强烈表达外,在细支气管、支气管上皮内也有灶性表达。SP-B是疏水性蛋白,主要效应是促进磷脂吸附和分布到肺泡气-液交界面,促进磷脂单分子层的形成,只有这种单分子层磷脂才能使表面张力降低到最低水平。Product Picture Sample:
Lane 1: Lung (Mouse) Lysate at 40 ug
Lane 2: Lung (Rat) Lysate at 40 ug
Lane 3: Molt-4 (Human) Cell Lysate at 30 ug
Lane 4: Hela (Human) Cell Lysate at 30 ug
Lane 5: A549 (Human) Cell Lysate at 30 ug
Primary: Anti-SP-B/Surfactant Protein B (SL22341R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 42 kD
Observed band size: 42 kD
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