Product Name	GASC1/KDM4C
Chinese Name	鳞状细胞癌增强蛋白1抗体
Alias	GASC 1 protein; GASC1 antibody Gene amplified in squamous cell carcinoma 1 protein; JHDM3C; JmjC domain containing histone demethylation protein 3C; Jumonji domain containing protein 2C; KDM4C_HUMAN.
Research Area	Tumour  immunology  Chromatin and nuclear signals
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:500-5000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	120kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human GASC1/KDM4C: 291-390/1056
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	KDM4C/JMJD2C, a jumonji domain containing protein, is a histone demethylase. JMJD2C specifically demethylates Lysine 9 and Lysine 36 residues of Histone H3, thereby playing a central role in regulating histone modifications. Function: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Subcellular Location: Nucleus. Tissue Specificity: Overexpressed in several esophageal squamous cell carcinomas (ESCs). Similarity: Belongs to the JHDM3 histone demethylase family. Contains 1 JmjC domain. Contains 1 JmjN domain. Contains 2 PHD-type zinc fingers. Contains 2 Tudor domains. SWISS: Q9H3R0 Gene ID: 23081 Database links: Entrez Gene: 23081 Human Entrez Gene: 76804 Mouse Entrez Gene: 298144 Rat Omim: 605469 Human SwissProt: Q9H3R0 Human SwissProt: Q8VCD7 Mouse Unigene: 709425 Human Unigene: 209059 Mouse
Product Picture	Sample: A431 (Human) Cell Lysate at 30 ug HepG2 (Human) Cell Lysate at 30 ug Hela (Human) Cell Lysate at 30 ug HL60 (Human) Cell Lysate at 30 ug Primary: Anti- GASC1/KDM4C (SL22322R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 100/120 kD Observed band size: 120 kD

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