Product Name	Cyclin A1
Chinese Name	周期素A1蛋白抗体
literatures	Specific References  (2)     |     SL22318R has been referenced in 2 publications. [IF=4.638] Li Li. et al. LAP3 contributes to IFN-γ-induced arginine depletion and malignant transformation of bovine mammary epithelial cells. BMC CANCER. 2022 Dec;22(1):1-19  WB ;  Bovine.   PubMed:35941558 [IF=2.13] Yusong Ge. et al. L-arginine stimulates the proliferation of mouse mammary epithelial cells and the development of mammary gland in pubertal mice by activating the GPRC6A/PI3K/AKT/mTOR signalling pathway. J ANIM PHYSIOL AN N. 2022 May 26  WB ;  Mouse.   PubMed:35616019
Research Area	Tumour  immunology  Cyclin
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse, Rat,  (predicted: Human, Cow, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	51kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Cyclin A1 : 391-465/465
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Cyclin A1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclin A1 is expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. It binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. Cyclin A1 was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Function: Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions. Subcellular Location: Nucleus. Cytoplasm. Cytoplasmic when associated with SCAPER. Similarity: Belongs to the cyclin family. Cyclin AB subfamily. SWISS: P78396 Gene ID: 8900 Database links: Entrez Gene: 8900 Human Entrez Gene: 12427 Mouse Omim: 604036 Human SwissProt: P78396 Human SwissProt: Q61456 Mouse Unigene: 417050 Human Unigene: 4815 Mouse
Product Picture	Sample: Testis (Mouse) Lysate at 40 ug Testis (Rat) Lysate at 40 ug Primary: Anti-Cyclin A1 (SL22318R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 52’54 kD Observed band size: 52 kD

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