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Rabbit Anti-IL26    antibody
Rabbit Anti-IL26 antibody
AK155; IL 26; IL-26; IL26_HUMAN; Interleukin 26; Interleukin-26; Protein AK155.
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  • NO.:SL22196R
    Clonality:Polyclonal
    Immunogen Species:Rabbit
    React Species:Human,
    Applications:WB
    concentration:1mg/ml
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Product Name IL26
Chinese Name 白介素26抗体
Alias AK155; IL 26; IL-26; IL26_HUMAN; Interleukin 26; Interleukin-26; Protein AK155.   
Research Area immunology  
Immunogen Species Rabbit
Clonality Polyclonal
React Species Human, 
Applications WB=1:500-2000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight 18kDa
Cellular localization Secretory protein 
Form Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human IL26 : 31-120/171 
Lsotype IgG
Purification affinity purified by Protein A
Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
Product Detail This gene was identified by its overexpression specifically in herpesvirus samimiri-transformed T cells. The encoded protein is a member of the IL10 family of cytokines. It is a secreted protein and may function as a homodimer. This protein is thought to contribute to the transformed phenotype of T cells after infection by herpesvirus samimiri. [provided by RefSeq]

Function:
May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin.

Subunit:
Homodimer.

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed in HVS transformed T-cells but not other T-cell lines or primary stimulated T-cells. Expressed in colonic T-cells including Th17 inflammatory T-cells; the expression is significantly increased in serum of patients with Crohn's disease (at protein level).

Similarity:
Belongs to the IL-10 family.

SWISS:
Q9NPH9

Gene ID:
55801

Database links:
Entrez Gene: 55801 Human

Omim: 605679 Human

SwissProt: Q9NPH9 Human

Unigene: 272350 Human



IL-26作为炎性cell factor,可通过多重效应参与炎症过程。
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Sample:
HL60 (Human) Cell Lysate at 30 ug
Primary: Anti- IL26 (SL22196R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 18 kD
Observed band size: 18 kD

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