TEL: +86 571 56623320 EMAIL: [email protected]
Product Name PTN Chinese Name 多效生长因子抗体 Alias pleiotrophin; HARP; HBBM; HBGAM; HBGF8; HBNF; HBNF1; Heparin Binding Growth Factor 8; Heparin binding neurite outgrowth promoting factor 1; heparin-binding growth associated molecule; NEGF1; Neurite Growth Promoting Factor 1; OSF-1; osteoblast-specific factor; PTN; PTN_HUMAN. Research Area Tumour Cell biology Neurobiology Signal transduction Growth factors and hormones Cytoskeleton Extracellular matrix Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, Rat, (predicted: Human, Horse, Rabbit, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 15kDa Cellular localization Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human PTN: 101-168/168 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Pleiotrophin is a heparin-binding growth factor involved in the differentiation and proliferation of neuronal tissue during embryogenesis, and also secreted by melanoma and breast carcinoma cells. Pleiotrophin exhibits mitogenic and angiogenic properties and has been shown to influence the vascular supply, expansion and metastasis of tumour cells.
Function:
Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation.
Subunit:
Interacts with ALK and NEK6.
Subcellular Location:
Secreted.
Tissue Specificity:
Osteoblast and brain.
Post-translational modifications:
Phosphorylated by NEK6.
Similarity:
Belongs to the pleiotrophin family.
SWISS:
P21246
Gene ID:
5764
Database links:
Entrez Gene: 5764 HumanEntrez Gene: 19242 Mouse
Omim: 162095 Human
SwissProt: P21246 Human
SwissProt: P63089 Mouse
Unigene: 371249 Human
Unigene: 279690 Mouse
Unigene: 1653 Rat
多效生长因子(pleiotrophin)是一种分泌性的生长因子,具有促进Tumour细胞的增殖与迁移,对Tumour血管的生成有促进作用。Product Picture Paraformaldehyde-fixed, paraffin embedded (mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PTN) Polyclonal Antibody, Unconjugated (SL21928R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PTN) Polyclonal Antibody, Unconjugated (SL21928R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Scan Wechat Qrcode