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Product Name Thyroid hormone receptor alpha Chinese Name 甲状腺激素受体α抗体 Alias AR7; c-erbA-1; C-erbA-alpha; CHNG6; EAR 7; EAR-7; EAR7; ERB-T-1; ERBA alpha; ERBA; ERBA Related 7; ERBA-related 7; ERBA1; NR1A1; Nuclear receptor subfamily 1 group A member 1; THA_HUMAN; THRA 1; THRA; THRA1; THRA2; Thyroid hormone receptor alpha; thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian); thyroid normone nuclear receptor alpha variant 1; triiodothyronine receptor; V-erbA-related protein 7. Research Area Cell biology Neurobiology Signal transduction Growth factors and hormones Endocrinopathy Immunogen Species Rabbit Clonality Polyclonal React Species Human, Mouse, (predicted: Rat, Dog, Pig, Cow, Rabbit, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 45/54kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Thyroid hormone receptor alpha : 1-100/490 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Thyroid hormone receptors (TR) are ligand dependent, intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences called hormone response elements following activation by the appropriate hormone. Thyroid hormones, through their interaction with TR, effect metabolic processes, growth and development in many tissues by regulating the expression of genes for growth hormone, malic enzyme and several hepatic proteins. There are two forms of TR; TR alpha (on chromosome 17) and TR beta (on chromosome 3). Each of these isoforms also has two isoforms; TR alpha 1 and TR alpha 2, and TR beta 1 and TR beta 2 respectively. TR alpha 1 and 2 are identical through amino acid 370, where their sequences diverge. TR alpha 2, which does not bind T3 and is a strong negative regulator of the functional TR, is 80 amino acids longer than TR alpha 1.
Function:
Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
Subunit:
Interacts with ncoa2.
Subcellular Location:
Nucleus.
Tissue Specificity:
After the mid-blastula transition (MBT), expressed throughout the deep cells, which give rise to the embryo proper. In adults, isoform 2 shows highest expression in the eye and liver. Expressed in adult gonads.
Similarity:
Belongs to the nuclear hormone receptor family. NR1 subfamily.
Contains 1 nuclear receptor DNA-binding domain.
SWISS:
P10827
Gene ID:
7067
Database links:Entrez Gene: 7067 Human
Entrez Gene: 21833 Mouse
Omim: 190120 Human
SwissProt: P10827 Human
SwissProt: P63058 Mouse
Unigene: 724 Human
Unigene: 265917 Mouse
Unigene: 442648 Mouse
Unigene: 11307 Rat
Product Picture Sample:
Lung (Mouse) Lysate at 40 ug
Hela(Human) Cell Lysate at 30 ug
K562(Human) Cell Lysate at 30 ug
HL60(Human) Cell Lysate at 30 ug
Primary: Anti- Thyroid hormone receptor alpha (SL21873R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 45'54 kD
Observed band size: 45'54 kD
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