Product Name	CLDN11
Chinese Name	少突胶质细胞Transmembrane protein抗体
Alias	CLD11_HUMAN; Oligodendrocyte Specific Protein; Oligodendrocyte transmembrane protein; Claudin 11; claudin11; claudin-11; CLDN 11; OSP; OTM.
literatures	Specific References  (5)     |     SL2183R has been referenced in 5 publications. [IF=4.2] Zhang, Weidong, et al. "Decrease in male mouse fertility by hydrogen sulfide and/or ammonia can Be inheritable." Chemosphere (2017).  IHC-P ;  Mouse.   PubMed:29202267 [IF=4.067] Wang X et al. LRRC75A antisense lncRNA1 knockout attenuates inflammatory responses of bovine mammary epithelial cells. International Journal of Biological Sciences. 2020; 16(2): 251-263.  WB&ICF ;  Bovine.   PubMed:doi:10.7150/ijbs.38214 [IF=2.9] Zhang, Jianhai, et al. "Sodium fluoride and sulfur dioxide affected male reproduction by disturbing blood-testis barrier in mice." Food and Chemical Toxicology (2016).  WB ;  Mouse.   PubMed:27237588 [IF=2.8] Zhai J et al. An increase of estrogen receptor α protein level regulates BDE-209-mediated blood-testis barrier disruption during spermatogenesis in F1 mice. (2018) Environ Sci Pollut Res Int.  WB,IHF&ICF ;  Mouse.   PubMed:30565106 [IF=2.118] Li X et al. Overexpression of lncRNA H19 changes basic characteristics and affects immune response of bovine mammary epithelial cells. PeerJ. 2019 Apr 5;7:e6715.  WB ;  Bovine.   PubMed:30984483
Research Area	Cell biology  Neurobiology  Signal transduction  Apoptosis
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	22kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Claudin-11: 101-218/218 <Cytoplasmic>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Oligodendrocyte specific protein (OSP)is the third most abundant component of central nervous system myelin. The claudin superfamily consists of many structurally related proteins. These proteins, which include claudin 1 through 18, are located in both epithelial and endothelial cells in all tight junction bearing tissues. Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. There is growing evidence that OSP/Claudin 11 determines the permeability between layers of myelin sheaths via focal adhesion. Its expression is highly regulated during development, suggesting that it may play an important role in the growth and differentiation of oligodendrocytes and other cells outside the CNS. In addition, the protein is a candidate autoantigen in the development of autoimmune demyelinating disease. Subunit: Interacts with tetraspanin-3/TSPAN3. Subcellular Location: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Similarity: Belongs to the claudin family. SWISS: O75508 Gene ID: 5010 Database links: Entrez Gene: 508268. Cow Entrez Gene: 5010 Human Entrez Gene: 18417 Mouse Entrez Gene: 84588 Rat Omim: 601326 Human SwissProt: Q3MHK4 Cow SwissProt: O75508 Human SwissProt: Q60771 Mouse SwissProt: Q99P82 Rat Unigene: 31595 Human Unigene: 4425 Mouse Unigene: 8282 Rat

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