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Product Name CLDN11 Chinese Name 少突胶质细胞Transmembrane protein抗体 Alias CLD11_MOUSE; CLD11_HUMAN; Oligodendrocyte Specific Protein; Oligodendrocyte transmembrane protein; Claudin 11; claudin11; claudin-11; CLDN 11; OSP; OTM. literatures Specific References (1) | SL21509R has been referenced in 1 publications.[IF=7.31] Longfei Xiao. et al. Curcumin Ameliorates Age-Induced Tight Junction Impaired in Porcine Sertoli Cells by Inactivating the NLRP3 Inflammasome through the AMPK/SIRT3/SOD2/mtROS Signaling Pathway. OXID MED CELL LONGEV. 2023;2023:1708251 WB,IF ; Pig,Mouse.Research Area Cell biology Neurobiology Signal transduction Apoptosis Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Rat, ) Applications WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 22kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from mouse Claudin 11: 150-207/207 <Cytoplasmic> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Oligodendrocyte specific protein (OSP)is the third most abundant component of central nervous system myelin. The claudin superfamily consists of many structurally related proteins. These proteins, which include claudin 1 through 18, are located in both epithelial and endothelial cells in all tight junction bearing tissues. Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. There is growing evidence that OSP/Claudin 11 determines the permeability between layers of myelin sheaths via focal adhesion. Its expression is highly regulated during development, suggesting that it may play an important role in the growth and differentiation of oligodendrocytes and other cells outside the CNS. In addition, the protein is a candidate autoantigen in the development of autoimmune demyelinating disease.
Subunit:
Interacts with tetraspanin-3/TSPAN3.
Subcellular Location:
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Similarity:
Belongs to the claudin family.
SWISS:
Q60771
Gene ID:
18417
Database links:Entrez Gene: 5010 Human
Entrez Gene: 18417 Mouse
Omim: 601326 Human
SwissProt: O75508 Human
SwissProt: Q60771 Mouse
Unigene: 31595 Human
Unigene: 4425 Mouse
Unigene: 8282 Rat
Product Picture Sample:
Testis (Mouse) Lysate at 40 ug
Primary: Anti-Claudin 11’Oligodendrocyte Specific Protein (SL21509R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 22 kD
Observed band size: 22 kD
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