Product Name	ARL13B
Chinese Name	ADP核糖基化因子样蛋白13b抗体
Alias	ADP Ribosylation Factor Like GTPase 13B; ADP-Ribosylation Factor-Like 2-Like 1; ARL2-Like Protein 1; ARL2L1; ADP-Ribosylation Factor-Like Protein 2-Like 1; ADP-Ribosylation Factor-Like Protein 13B; ADP-Ribosylation Factor Like GTPase 13B; ADP-Ribosylation Factor-Like 13B; JBTS8; AR13B_HUMAN;
Research Area	Developmental biology  Neurobiology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse, Rat,  (predicted: Human, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	49kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ARL13B
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the ADP-ribosylation factor-like family. The encoded protein is a small GTPase that contains both N-terminal and C-terminal guanine nucleotide-binding motifs. This protein is localized in the cilia and plays a role in cilia formation and in maintenance of cilia. Mutations in this gene are the cause of Joubert syndrome 8. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] Function: Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic interneurons in the developing cerebral cortex. May regulate endocytic recycling traffic; however, additional evidences are required to confirm these data. Subunit: Monomer (By similarity). Interacts with PIFO. Interacts with IFT complex B components IFT46 and IFT74. Subcellular Location: Plasma membrane Tissue Specificity: Expressed in the developing brain. Post-translational modifications: Sumoylation is required for PKD2 entry into cilium. Similarity: Belongs to the small GTPase superfamily. Arf family. SWISS: Q3SXY8 Gene ID: 200894 Database links: Entrez Gene: 200894 Human Entrez Gene: 68146 Mouse Entrez Gene: 304037 Rat Omim: 608922 Human SwissProt: Q3SXY8 Human SwissProt: Q640N2 Mouse Unigene: 533086 Human Unigene: 96833 Mouse Unigene: 30700 Rat
Product Picture	Sample: SiHa (Human) Cell Lysate at 30 ug Primary: Anti-ARL13B (SL21493R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 49 kD Observed band size: 49 kD Sample: Cerebrum (Rat) Lysate at 40 ug Cerebrum (Mouse) Lysate at 40 ug Primary: Anti- ARL13B (SL21493R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 49 kD Observed band size: 49 kD

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