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Product Name Neurotrophin 3 Chinese Name 神经营养因子-3前蛋白抗体 Alias HDNF; MGC129711; Nerve growth factor 2; Neurotrophic factor; Neurotrophin 3 precursor; Neurotrophin-3; Neurotrophin3; NGF 2; NGF-2; NGF2; NT 3; NT-3; NT3; NTF 3; NTF3; NTF3_HUMAN. Research Area immunology Neurobiology Immunogen Species Rabbit Clonality Polyclonal React Species Rat, (predicted: Human, Mouse, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 28kDa Cellular localization Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Neurotrophin 3 : 131-230/257 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008].
Function:
Seems to promote the survival of visceral and proprioceptive sensory neurons.
Subcellular Location:
Secreted.
Tissue Specificity:
Brain and peripheral tissues.
Similarity:
Belongs to the NGF-beta family.
SWISS:
P20783
Gene ID:
4908
Database links:
Entrez Gene: 4908 HumanEntrez Gene: 18205 Mouse
Omim: 162660 Human
SwissProt: P20783 Human
SwissProt: P20181 Mouse
Unigene: 99171 Human
Unigene: 267570 Mouse
Unigene: 9715 Rat
Neurobiology相关蛋白(Neurobiology) 一种内源型神经递质,分子量为28kDa的碱性多肽,属神经营养蛋白家族。与NGF和BDNF具有序列同源性,为培养的神经嵴细胞的促细胞分裂剂。此抗体与NGF、BDNF无React Species。Product Picture Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Neurotrophin 3) Polyclonal Antibody, Unconjugated (SL21489R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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