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Product Name NCR1 Chinese Name 细胞毒性受体NK-p46抗体 Alias Natural killer cell p46-related protein; Natural cytotoxicity triggering receptor 1; NK-p46; NKp46; NK cell-activating receptor; Lymphocyte antigen 94 homolog; CD335; CD 335; LY94; NCTR1_HUMAN. Research Area Tumour Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Human, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 31kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human NCR1 : 198-206/304 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The natural cytotoxicity receptors (NCRs) are a recently characterized family of Ig-like activation receptors that appear to be major triggering receptors in tumor cell recognition. NCR1 is a glycoprotein that has two extracellular Ig-like domains followed by a ~40 amino acid residue stalk region, a type I transmembrane domain, and a short cytoplasmic tail. NCR1 has been shown to represent a novel NK cell-specific molecule involved in human NK cell activation. NCR1 has been implicated in NK cell-mediated lysis of several autologous tumor cells and pathogen-infected cell lines.
Function:
Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.
Subunit:
Interacts with CD247 and FCER1G.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein.
Tissue Specificity:
Selectively expressed by both resting and activated NK cells.
Similarity:
Belongs to the natural cytotoxicity receptor (NCR) family.
Contains 2 Ig-like (immunoglobulin-like) domains.
SWISS:
O76036
Gene ID:
9437
Database links:Entrez Gene: 9437 Human
Entrez Gene: 17086 Mouse
Omim: 604530 Human
SwissProt: O76036 Human
SwissProt: Q8C567 Mouse
Unigene: 97084 Human
Unigene: 240231 Mouse
Unigene: 30049 Rat
NKp46是很重要的的自然细胞毒受体,在自然杀伤作用中起关键作用。细胞毒性受体家族(NCRs)主要有:NKp46、NKp44和NKp30,其中NKp46和NKp30表达于所有静止和活化的NK细胞,而NKp44则选择性的表达于活化的NK细胞。靶细胞上的配体分子与NCRs的结合(交联)引发NK细胞的活化导致靶细胞的裂解和大量cell factor的产生。现已确认NKp46和NKp44可以识别病毒上的配体分子红血球凝聚素,而NKp46则能识别Tumour细胞上的乙酰硫酸多聚糖。Product Picture
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