Product Name	PAIP2
Chinese Name	多聚腺苷酸Binding protein相互作用蛋白2抗体
Alias	PABP-interacting protein 2; PAIP-2; PAIP2; PAIP2_HUMAN; poly(A) binding protein interacting protein 2; Poly(A)-binding protein-interacting protein 2; Polyadenylate-binding protein-interacting protein 2.
Research Area	Cell biology  Signal transduction  transcriptional regulatory factor  Binding protein  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	15kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PAIP2: 51-127/127
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	PAIP2 (Poly(A) Binding Protein Interacting Protein 2) is a Protein Coding gene. Among its related pathways are Translational Control and TGF-Beta Pathway. GO annotations related to this gene include mRNA binding and translation repressor activity. An important paralog of this gene is PAIP2B. Function: Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization. Subunit: Interacts with the RRM1-RRM2 and C-terminus regions of PABPC1 in a 1:1 stoichiometry. Interacts with EIF4A. Subcellular Location: Cytoplasm. Similarity: Belongs to the PAIP2 family. SWISS: Q9BPZ3 Gene ID: 51247 Database links: Entrez Gene: 416187 Chicken Entrez Gene: 536619 Cow Entrez Gene: 51247 Human Entrez Gene: 67869 Mouse Entrez Gene: 361309 Rat Omim: 605604 Human SwissProt: Q5ZJS6 Chicken SwissProt: Q3ZC67 Cow SwissProt: Q9BPZ3 Human SwissProt: Q9D6V8 Mouse SwissProt: Q6AXZ0 Rat Unigene: 396644 Human Unigene: 126534 Mouse Unigene: 1073 Rat

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