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Product Name Tristetraprolin/ZFP36 Chinese Name Tristetraprolin抗体 Alias G0/G1 switch regulatory protein 24; G0S24; Growth factor-inducible nuclear protein NUP475; NUP475; Protein TIS11A; RNF162A; TIS 11; TIS11; TIS11A; Tristetraprolin; Tristetraproline; TTP; TTP_HUMAN; Zfp-36; ZFP36; Zinc finger protein 36; Zinc finger protein 36 homolog; Zinc finger protein 36, C3H type, homolog (mouse); Zinc finger protein, C3H type, 36 homolog. Research Area immunology Chromatin and nuclear signals Neurobiology Signal transduction Growth factors and hormones Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 35kDa Cellular localization The nucleus cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Tristetraprolin: 101-200/319 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail ZFP36 (ZFP36 Ring Finger Protein) is a Protein Coding gene. Among its related pathways are Spinal Cord Injury and ErbB1 downstream signaling. GO annotations related to this gene include poly(A) RNA binding and enzyme binding. An important paralog of this gene is ZFP36L2.
Function:
mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. Acts by specifically binding ARE-containing mRNAs and promoting their degradation. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1. Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF). Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF).
Subunit:
Interacts (via C-terminus) with CNOT1.
Subcellular Location:
Nucleus {ECO:0000269|PubMed:15014438}. Cytoplasm {ECO:0000269|PubMed:15014438}. Note=Localizes to stress granules upon energy starvation. phosphorylation by MAPKAPK2 promotes exclusion from stress granules.
Post-translational modifications:
Phosphorylation by MAPKAPK2 increases its stability and binding to 14-3-3 proteins, leading to reduce its ARE affinity leading to inhibition of degradation of ARE-containing transcripts. Phosphorylated upon mitogen stimulation.
Similarity:
Contains 2 C3H1-type zinc fingers.
SWISS:
P26651
Gene ID:
7538
Database links:Entrez Gene: 7538 Human
Omim: 190700 Human
SwissProt: P26651 Human
Unigene: 534052 Human
Unigene: 728064 Human
Unigene: 82737 Rat
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