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Product Name SLC19A1 Chinese Name 溶质载体家族蛋白19成员A1抗体 Alias CHMD; FLOT 1; FLOT1; Folate transporter 1; FOLT; IFC 1; IFC-1; IFC1; Intestinal folate carrier 1; Intestinal folate carrier; OTTHUMP00000115459; OTTHUMP00000115460; Placental folate transporter; Reduced folate carrier; Reduced folate carrier protein; REFC; RFC 1; RFC; RFC1; S19A1_MOUSE; SLC19A1; Solute carrier family 19 member 1. Research Area Tumour Cell biology Signal transduction Transporter The cell membrane蛋白 Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Rat, ) Applications WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 64kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from mouse SLC19A1: 101-200/512 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail SLC19A1 (Solute Carrier Family 19 (Folate Transporter), Member 1) is a Protein Coding gene. Diseases associated with SLC19A1 include placental choriocarcinoma and thiamine-responsive megaloblastic anemia syndrome. Among its related pathways are Cell Cycle, Mitotic and Metabolism. GO annotations related to this gene include oxidoreductase activity and folic acid transporter activity. An important paralog of this gene is SLC19A2.
Function:
Transporter for the intake of folate. Uptake of folate in human placental choriocarcinoma cells occurs by a novel mechanism called potocytosis which functionally couples three components, namely the folate receptor, the folate transporter, and a V-type H(+)-pump.
Subcellular Location:
Membrane.
Tissue Specificity:
Placenta, liver, and to a much smaller extent, in lung.
Post-translational modifications:
Heavily glycosylated.
Similarity:
Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
SWISS:
P41438
Gene ID:
20509
Database links:Entrez Gene: 6573 Human
Entrez Gene: 20509 Mouse
Omim: 600424 Human
SwissProt: P41440 Human
SwissProt: P41438 Mouse
Unigene: 84190 Human
Unigene: 9042 Rat
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