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Product Name CCL27 Chinese Name 皮肤T细胞虏获Chemokine抗体 Alias ALP; CTACK; C-C motif chemokine 27; CC chemokine ILC; Ccl27; CTAK; Cutaneous T cell attracting chemokine; Cutaneous T-cell-attracting chemokine; ESkine; IL 11 R alpha locus chemokine; IL-11 R-alpha-locus chemokine; PESKY; SCYA27; Skinkine; Small inducible cytokine A27; Small-inducible cytokine A27. Research Area immunology Chemokine Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Mouse, Rat, ) Applications ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 19kDa Cellular localization Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from mouse CCL27: 26-100/120 Lsotype IgG Purification affinity purified by Protein A Buffer Solution Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. This cytokine may also play a role in mediating homing of lymphocytes to cutaneous sites. It specifically binds to chemokine receptor 10 (CCR10). Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. [provided by RefSeq].
Function:
Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. Binds to CCR10.
Subunit:
Monomer, dimer, and tetramer. Heparin avidly promotes oligomerization.
Subcellular Location:
Secreted.
Tissue Specificity:
Testis, thymus, placenta, ovary and skin.
Similarity:
Belongs to the intercrine beta (chemokine CC) family.
SWISS:
Q9Z1X0
Gene ID:
20301
Database links:Entrez Gene: 100039863 Mouse
Entrez Gene: 100039939 Mouse
Entrez Gene: 100040048 Mouse
Entrez Gene: 20301 Mouse
SwissProt: Q9Z1X0 Mouse
Unigene: 335946 Mouse
Unigene: 425176 Mouse
Unigene: 484274 Mouse
Unigene: 6660 Mouse
Unigene: 78371 Rat
CCL27是一种CC型Chemokine,又被称为Skinkine,ESkine和CTACK。CCL27基因位于人类染色体9,它与皮肤上归巢的记忆Tlymphocyte有关,并在T细胞介导的皮肤炎症中起着重要的作用。CCL27表达在许多组织,包括性腺,胸腺,胎盘和皮肤。其配体为CCR10,CCL27与接触性软疣病毒编码产生的蛋白质MC148有较高的同源性,但却与人疱疹病毒8型编码产生病毒巨噬细胞炎症蛋白-Ⅱ竞争结合受体CCR10。
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