Product Name	UCP-2
Chinese Name	Mitochondrion脱偶连蛋白2抗体
Alias	Uncoupling Protein-2; UCP2; UCP 2; BMIQ4; Mitochondrial uncoupling protein 2; SLC25A8; UCPH; Uncoupling protein 2; Uncoupling protein 2 mitochondrial proton carrier; Solute carrier family 25 member 8; UCP2_HUMAN.
literatures	Specific References  (2)     |     SL20751R has been referenced in 2 publications. [IF=3.038] Lan Yang et al. The Involvement of Mitochondrial Biogenesis in Selenium Reduced Hyperglycemia-Aggravated Cerebral Ischemia Injury. Neurochem Res. 2020 Aug;45(8):1888-1901.  WB ;  Mouse.   PubMed:32447509 [IF=2.22] Ya Sun. et al. Expression and hormone regulation of UCP2 in goat uterus. ANIM REPROD SCI. 2022 Aug;243:107015  WB, IHC ;  Goat.   PubMed:35689907
Research Area	Cell biology  immunology  Chromatin and nuclear signals  Diabetes
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	34kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human UCP-2: 51-120/309
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. UCP2 gene is expressed in many tissues, with the greatest expression in skeletal muscle. UCP2 is thought to play a role in non shivering thermogenesis, obesity and diabetes. Function: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. Subunit: Acts as a dimer forming a proton channel. Subcellular Location: Mitochondrion inner membrane; Multi-pass membrane protein. Tissue Specificity: Widely expressed in adult human tissues, including tissues rich in macrophages. Most expressed in white adipose tissue and skeletal muscle. Similarity: Belongs to the mitochondrial carrier family. Contains 3 Solcar repeats. SWISS: P55851 Gene ID: 7351 Database links: Entrez Gene: 7351 Human Entrez Gene: 54315 Rat Omim: 601693 Human SwissProt: P55851 Human SwissProt: P56500 Rat Unigene: 80658 Human Unigene: 13333 Rat UCP-2又称解耦联蛋白 2 (UCP2 )是 1997年发现的一种新的解偶联蛋白 ,它是Mitochondrion内膜载体家族的一员 。与其类似物UCP1相比 ,UCP2在棕色脂肪组织中含量较低 ,但在体内分布广泛。解耦联蛋白(UCP)具有使Mitochondrion呼吸链解耦联作用,解耦联所释放的能量以热能的形式散发。在对UCP与产热关系的研究中,发现UCP2具有调节机体能量代谢的功能,并且可能是肥胖与2型Diabetes相关联的一个重要基因。
Product Picture	Sample: Hela(Human) Cell Lysate at 30 ug Primary: Anti-UCP-2 (SL20751R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 34 kD Observed band size: 34 kD Sample: SP2/0 cell(human) Lysate at 30 ug A673 cell(human) Lysate at 30 ug Primary: Anti- UCP2 (SL20751R) at 1/2000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 34kD Observed band size: 34kD Sample: Skeletal muscle (Mouse) Lysate at 40 ug Primary: Anti- UCP-2 (SL20751R) at 1/500 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 34 kD Observed band size: 35 kD Sample: TT(Human) Cell Lysate at 30 ug Primary: Anti-UCP-2 (SL20751R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 34 kD Observed band size: 34 kD Paraformaldehyde-fixed, paraffin embedded (rat skeletal muscle); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (UCP-2) Polyclonal Antibody, Unconjugated (SL20751R) at 1:400 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.

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