Product Name	FSH receptor
Chinese Name	促卵泡刺激素受体抗体
Alias	Follicle-stimulating hormone receptor precursor; Follicle stimulating hormone receptor; Follicle stimulating hormone receptor isoform 1; Follitropin receptor; FSHRO; LGR1; ODG1; Follicle-stimulating hormone receptor; FSH-R; FSH R; Fshr; FSHR_HUMAN; MGC141667; MGC141668; ovarian dysgenesis 1.
literatures	Specific References  (7)     |     SL20658R has been referenced in 7 publications. [IF=6.208] Sijie Fan. et al. Seasonal Change in Adiponectin Associated with Ovarian Morphology and Function in Wild Ground Squirrels (Citellus dauricus Brandt). INT J MOL SCI. 2022 Jan;23(23):14698  IHC ;  Squirrel.   PubMed:36499026 [IF=5.108] Yang Z et al. A pilot study on polycystic ovarian syndrome caused by neonatal exposure to tributyltin and bisphenol A in rats. Chemosphere. 2019 Sep;231:151-160.  WB ;  Rat.   PubMed:31129395 [IF=4.982] Luo, Qianqian. et al. hUCMSCs reduce theca interstitial cells apoptosis and restore ovarian function in premature ovarian insufficiency rats through regulating NR4A1-mediated mitochondrial mechanisms. REPROD BIOL ENDOCRIN. 2022 Dec;20(1):1-14  IF ;  Rat.   PubMed:35986315 [IF=4.627] Wang Q et al. Heat shock pretreatment improves mesenchymal stem cell viability by heat shock proteins and autophagy to prevent cisplatin-induced granulosa cell apoptosis. Stem Cell Res Ther. 2019 Nov 26;10(1):348.  ICC ;  Rat.   PubMed:31771642 [IF=2.589] Zhou Z et al. Maternal high-fat diet impairs follicular development of offspring through intraovarian kisspeptin/GPR54 system. Reprod Biol Endocrinol. 2019 Jan 22;17(1):13.  IHC-P ;  Rat.   PubMed:30670046 [IF=1.54] Xiyan Wang. et al. The optimized research of the in vitro culture of preantral follicles in mice. J Clin Lab Anal. 2020 Nov;34(11):e23498  WB,IF ;  Mouse.   PubMed:33463764 [IF=1.36] Wang, Junjie, et al. "Seasonal expression of luteinizing hormone receptor and follicle stimulating hormone receptor in testes of the wild ground squirrels (Citellus dauricus Brandt)." Acta Histochemica (2017).  WB ;  Other Species.   PubMed:28912046
Research Area	Cell biology  Developmental biology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, Horse, Sheep, )
Applications	WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/Test IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	78kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human FSH receptor: 21-100/695 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] Function: Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Subunit: Interacts with ARRB2. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Sertoli cells and ovarian granulosa cells. DISEASE: Defects in FSHR are a cause of ovarian dysgenesis type 1 (ODG1) [MIM:233300]; also known as premature ovarian failure or gonadal dysgenesis XX type or XX gonadal dysgenesis (XXGD) or hereditary hypergonadotropic ovarian failure or hypergonadotropic ovarian dysgenesis with normal karyotype. ODG1 is an autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, and high serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Defects in FSHR are a cause of ovarian hyperstimulation syndrome (OHSS) [MIM:608115]. OHSS is a disorder which occurs either spontaneously or most often as an iatrogenic complication of ovarian stimulation treatments for in vitro fertilization. The clinical manifestations vary from abdominal distention and discomfort to potentially life-threatening, massive ovarian enlargement and capillary leak with fluid sequestration. Pathologic features of this syndrome include the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells, a condition called hyperreactio luteinalis. Similarity: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. Contains 9 LRR (leucine-rich) repeats. Contains 1 LRRNT domain. SWISS: P23945 Gene ID: 2492 Database links: Entrez Gene: 281172 Cow Entrez Gene: 100861291 Goat Entrez Gene: 2492 Human Entrez Gene: 14309 Mouse Entrez Gene: 397679 Pig Entrez Gene: 25449 Rat Entrez Gene: 443299 Sheep Omim: 136435 Human SwissProt: P35376 Cow SwissProt: P23945 Human SwissProt: P35378 Mouse SwissProt: P49059 Pig SwissProt: P20395 Rat SwissProt: P35379 Sheep Unigene: 1428 Human Unigene: 57155 Mouse Unigene: 162843 Rat FSHR属于G protein-coupled receptor超家族中的glycoprotein亚家族成员，Transmembrane protein。人类的FSHR是由695个氨基酸组成的一条肽链，主要分布于睾丸支持细胞和卵巢颗粒细胞
Product Picture	Sample: Ovary (mouse) Lysate at 40 ug Primary: Anti- FSH receptor (SL20658R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 78kD Observed band size: 78kD Paraformaldehyde-fixed, paraffin embedded (rat ovary); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (FSH receptor ) Polyclonal Antibody, Unconjugated (SL20658R) at 1:400 overnight at 4°C, followed by a conjugated secondary antibody (sp-0023) for 20 minutes and DAB staining. Paraformaldehyde-fixed, paraffin embedded (rat testis); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CBFb) Polyclonal Antibody, Unconjugated (SL20658R ) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Blank control (blue line): MCF7 (fixed with 70% methanol overnight at 4℃). Primary Antibody (green line): Rabbit Anti-FSH receptor antibody (SL20658R) ,Dilution: 0.2μg /10^6 cells; Isotype Control Antibody (orange line): Rabbit IgG . Secondary Antibody (white blue line): Goat anti-rabbit IgG-PE,Dilution: 1μg /test.

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