Product Name	NCX3
Chinese Name	钠钙Exchange protein3抗体
Alias	AW742262; MGC90626; Na(+)/Ca(2+)-exchange protein 3; Na+/Ca2+ exchange protein 3; Na+/Ca2+ exchanger 3; NAC3_HUMAN; NCX3; SCL8A3; Sodium calcium exchanger form 3; Sodium/calcium exchanger 3; Sodium/calcium exchanger SLC8A3; Solute carrier family 8 sodium calcium exchanger member 3.
literatures	Specific References  (1)     |     SL2057R has been referenced in 1 publications. [IF=3.201] Zhang J et al. TRPV4 Complexes With the Na/Ca 2 Exchanger and IP 3 Receptor 1 to Regulate Local Intracellular Calcium and Tracheal Tension in Mice. Front. Physiol., 06 December 2019.  Co-IP&WB ;  Mouse.   PubMed:doi:10.3389/fphys.2019.01471
Research Area	Tumour  Neurobiology  Signal transduction  The new supersedes the old
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	100kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human NCX3: 641-740/927 <Cytoplasmic>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	SLC8A3 is a member of the sodium/calcium exchanger integral membrane protein family. Three mammalian isoforms in family 8 have been identified. Na+/Ca2+ exchange proteins are involved in maintaining Ca2+ homeostasis in a wide variety of cell types. The protein is regulated by intracellular calcium ions and is found in both the plasma membrane and intracellular organellar membranes, where exchange of Na+ for Ca2+ occurs in an electrogenic manner. Function: Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores (By similarity). Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Isoform 2 is expressed in brain and skeletal muscle. Isoform 3 is expressed in excitable cells of brain, retina and skeletal muscle. Isoform 4 is expressed in skeletal muscle. Similarity: Belongs to the sodium/potassium/calcium exchangerv family. SLC8 subfamily. Contains 2 Calx-beta domains. SWISS: P57103 Gene ID: 6547 Database links: Entrez Gene: 6547 Human Entrez Gene: 110893 Mouse Entrez Gene: 140448 Rat Omim: 607991 Human SwissProt: P57103 Human SwissProt: P70549 Rat Unigene: 337696 Human Unigene: 443748 Mouse Unigene: 67030 Rat 钠钙Exchange protein又称钠钙交换体，有三种同分异构体,即NCX1、NCX2和NCX3。3型Na-CaExchange protein-NCX3, 主要在脑组织表达，分布与胞浆及胞膜。

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