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Product Name PFKP Chinese Name 6-磷酸果糖激酶C抗体 Alias 1200015H23Rik; 6 phosphofructokinase type C; 6 phosphofructokinase, platelet type; 6-phosphofructokinase; 6-phosphofructokinase type C; 9330125N24Rik; FLJ40226; K6PP; K6PP_HUMAN; MGC105718; PFK C; PFK, fibroblast type; PFK-C; PFKF; Phosphofructo 1 kinase isozyme C; Phosphofructo-1-kinase isozyme C; Phosphofructokinase 1; Phosphofructokinase platelet; Phosphohexokinase; platelet type. Research Area Tumour Cell biology Signal transduction Kinases and Phosphatases Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 86kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human PFKP: 231-330/784 Lsotype IgG Purification affinity purified by Protein A Buffer Solution Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The PFKP gene encodes the platelet isoform of phosphofructokinase (PFK) (ATP:D-fructose-6-phosphate-1-phosphotransferase, EC 2.7.1.11). PFK catalyzes the irreversible conversion of fructose-6-phosphate to fructose-1,6-bisphosphate and is a key regulatory enzyme in glycolysis. The PFKP gene, which maps to chromosome 10p, is also expressed in fibroblasts. See also the muscle (PFKM; MIM 610681) and liver (PFKL; MIM 171860) isoforms of phosphofructokinase, which map to chromosomes 12q13 and 21q22, respectively. Vora (1981) [PubMed 6451249] determined that full tetrameric phophofructokinase enzyme expressed in platelets can be composed of subunits P4, P3L, and P2L2.[supplied by OMIM, Mar 2008]
Function:
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
Subunit:
Homo- and heterotetramers. Muscle is M4, liver is L4, and red cell is M3L, M2L2, or ML3. A subunit composition with a higher proportion of platelet type subunits is found in platelets, brain and fibroblasts.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
GlcNAcylation decreases enzyme activity.
Similarity:
Belongs to the phosphofructokinase family. Two domains subfamily.
SWISS:
Q01813
Gene ID:
5214
Database links:Entrez Gene: 5214 Human
Entrez Gene: 56421 Mouse
Omim: 171840 Human
SwissProt: Q01813 Human
SwissProt: Q9WUA3 Mouse
Unigene: 26010 Human
Unigene: 273874 Mouse
Unigene: 2278 Rat
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