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Product Name CASP4 Chinese Name 半胱胺酸蛋白酶蛋白-4抗体 Alias Caspase-4 subunit 2; Caspase-4 subunit p10; Caspase-11; CASP-11; Protease ICH-3; Apoptosis related cysteine peptidase; Apoptotic cysteine protease Mih1/TX; CASP 4; CASP 4; CASP-4; CASP4; CASP4_HUMAN; CASP4_MOUSE; Caspase 4 apoptosis related cysteine peptidase; Caspase-4 subunit 2; Caspase4; ICE(rel) II; ICE(rel)-II; ICE(rel)II; ICEREL II; ICERELII; ICH 2; ICH 2 protease; ICH2; Mih1/TX; Mih1/TX; Protease ICH-2; Protease TX; TX; TX protease; EC:3.4.22.64. Research Area Tumour Cell biology Stem cells Apoptosis Immunogen Species Rabbit Clonality Polyclonal React Species Rat, (predicted: Mouse, ) Applications WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 10/43kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from mouse Caspase-4 subunit p10: 251-350/373 Lsotype IgG Purification affinity purified by Protein A Buffer Solution Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Caspase 4 is a 377 amino acid protein (43 kDa) that belongs to the Ced3/ICE family of cystein proteases. Caspase 4 is an "upstream" caspase with a long prodomain. It undergoes a cleavage upon activation, leading to p20 and p10 subunits which have 67% homology to mature Caspase 1 over the equivalent coding sequences. Caspase 4 is capable of cleaving itself and the p30 Caspase 1 precursor, and of inducing apoptosis in transfected insect or COS cells. In high concentrations, it can also cleave the nuclear DNA enzyme PARP but the biological relevance of this cleavage is unclear. Caspase 4 mRNA is found in most tissues examined with the exception of the brain. Highest expression is found in spleen and lung, with moderate expression in heart and liver. Low expression is observed with skeletal muscle, kidney, and testis.
Function:
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1.
Subunit:
Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a small and a large subunit.
Tissue Specificity:
Widely expressed, with highest levels in spleen and lung. Moderate expression in heart and liver, low expression in skeletal muscle, kidney and testis. Not found in the brain.
Post-translational modifications:
The two subunits are derived from the precursor sequence by an autocatalytic mechanism or by cleavage by Caspase-8.
Similarity:
Belongs to the peptidase C14A family.
Contains 1 CARD domain.
SWISS:
P49662
Gene ID:
12363
Database links:
Entrez Gene: 837 Human
Entrez Gene: 12363 Mouse
Omim: 602664 Human
SwissProt: P49662 Human
SwissProt: P70343 Mouse
Unigene: 138378 Human
Unigene: 1569 Mouse
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