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Product Name CBY1 Chinese Name 富含亮氨酸胞浆蛋白CBY1抗体 Alias PGEA1; CBY1; C22orf2; CBY; Cytosolic leucine rich protein; HRIHFB2025; PIGEA 14; PIGEA-14; PKD2 interactor, Golgi and endoplasmic reticulum-associated 1; Protein Chibby. Research Area Tumour Cell biology Neurobiology Signal transduction Stem cells transcriptional regulatory factor Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, ) Applications ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 14kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human CBY1: 51-126/126 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function:
TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation.
Subunit:
Homodimer. Interacts with polycystin-2/PKD2 and GM130. Interacts with the C-terminal region of beta-catenin.
Subcellular Location:
Nucleus speckle. Golgi apparatus, trans Golgi network. Note: Nuclear, in a punctate manner. Also found in the trans Golgi.
DISEASE:
Widely expressed. Expressed at higher levels in heart, skeletal muscle, kidney and placenta. Also found in brain, lung, liver and testis. Significantly down-regulated in thyroid and metastatic uterine tumors.
Similarity:
Belongs to the chibby family.
SWISS:
Q9Y3M2
Gene ID:
25776
Database links:Entrez Gene: 25776 Human
SwissProt: Q9Y3M2 Human
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