Product Name	SCP2
Chinese Name	固醇携带蛋白2抗体
Alias	DKFZp686C12188; DKFZp686D11188; NLTP; Nonspecific lipid transfer protein; NSL TP; OTTHUMP00000010488; Propanoyl CoA C acyltransferase; SCP 2; SCP chi; SCP X; SCP2; SCPchi; SCPX; Sterol carrier protein 2; Sterol carrier protein X; NLTP_HUMAN.
Research Area	Cardiovascular  Cell biology  immunology  Chromatin and nuclear signals  Cyclin  Synthesis and Degradation  Cell differentiation  Cytoskeleton  Mitochondrion
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Cow, Rabbit, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	59kDa
Cellular localization	cytoplasmic Mitochondrion
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SCP2: 451-547/547
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes two proteins: sterol carrier protein X(SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. [provided by RefSeq, Aug 2010] Function: Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis. Subunit: Interacts with PEX5. Subcellular Location: Cytoplasm. Mitochondrion. Note=Cytoplasmic in the liver and also associated with mitochondria especially in steroidogenic tissues. Isoform SCPx: Peroxisome. Note=Interaction with PEX5 is essential for peroxisomal import. Isoform SCP2: Mitochondrion (Probable). Tissue Specificity: Liver, fibroblasts, and placenta. DISEASE: Leukoencephalopathy, with dystonia and motor neuropathy (LDMN) [MIM:613724]: A syndrome characterized by leukoencephalopathy, dystonic head tremor, spasmodic torticollis and reduced tendon reflexes in lower extremities. Additional features include hyposmia, pathologic saccadic eye movements, a slight hypoacusis, accumulation of branched-chain pristanic acid in plasma, and the presence of abnormal bile alcohol glucuronides in urine. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: In the N-terminal section; belongs to the thiolase family. Contains 1 SCP2 domain. SWISS: P22307 Gene ID: 6342 Database links: Entrez Gene: 6342 Human Entrez Gene: 20280 Mouse Entrez Gene: 25541 Rat Omim: 184755 Human SwissProt: P22307 Human SwissProt: P32020 Mouse SwissProt: P11915 Rat Unigene: 476365 Human Unigene: 379011 Mouse Unigene: 31887 Rat 固醇携带蛋白2(SCP2)参与了胆固醇的合成、代谢和转运过程.与胆囊固醇结石形成有关.

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