Product Name	ARL8B
Chinese Name	ADP核糖基化样因子8B抗体
Alias	ADP ribosylation factor like 10C; ADP-ribosylation factor-like protein 10C; ADP-ribosylation factor-like protein 8B; ARL10C; ARL8B; ARL8B_HUMAN; FLJ10702; Gie1; Novel small G protein indispensable for equal chromosome segregation 1.
Research Area	Cell biology  Cyclin  Cell differentiation  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Cow, Rabbit, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	22kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ARL8B: 1-100/186
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	ADP-ribosylation factors (ARFs) are highly conserved guanine nucleotide binding proteins that enhance the ADP-ribosyltransferase activity of Cholera Toxin. ARF’s are important in eukaryotic vesicular trafficking pathways and they play an essential role in the activation of phospholipase D (PC-PLD). ARL8B (ADP-ribosylation factor-like protein 8B), also known as ARL10C or GIE1, is a 186 amino acid protein that localizes to the late endosome membrane and belongs to the ARL family of ARF-like GTPase proteins. Expressed ubiquitously, ARL8A interacts with Tubulin and is thought to play a role in lysosome motility, as well as in chromosomal segregation. The gene encoding ARL8B maps to human chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci. Function: May play a role in lysosome motility (PubMed:16537643). May play a role in chromosome segregation (PubMed:15331635). Subunit: Interacts with tubulin. Subcellular Location: Late endosome membrane. Lysosome membrane. Cytoplasm, cytoskeleton, spindle. Tissue Specificity: Ubiquitously expressed. Similarity: Belongs to the small GTPase superfamily. Arf family. SWISS: Q9NVJ2 Gene ID: 55207 Database links: Entrez Gene: 55207 Human SwissProt: Q9NVJ2 Human Unigene: 250009 Human

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