Product Name	Endokinin-C
Chinese Name	Endokinin-C抗体
Alias	EK; Endokinin; HK 1; HK1; TKN4_HUMAN; Preprotachykinin C; TAC4; Tachykinin 4 (hemokinin); Tachykinin 4; Endokinin C.
Research Area	Cell biology  immunology  Neurobiology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	1.5kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Endokinin-C: 41-113/113
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene is a member of the tachykinin family of neurotransmitter-encoding genes. Tachykinin proteins are cleaved into small, secreted peptides that activate members of a family of receptor proteins. The products of this gene preferentially activate tachykinin receptor 1, and are thought to regulate peripheral endocrine and paracrine functions including blood pressure, the immune system, and endocrine gland secretion. The products of this gene lack a dibasic cleavage site found in other tachykinin proteins. Consequently, the nature of the cleavage products generated in vivo remains to be determined. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Function: Hemokinin 1 are from the Tachykinins family of proteins that are active peptides which excite neurons. They evoke behavioral responses and are potent vasodilators and secretagogues. Hemokinin 1 involved in contraction (directly or indirectly) of many smooth muscles. Hemokinin 1is cleaved in to three short peptides Edokinin A,B,C. Endokinin A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with Endokinin C. Endokinin A/B reduces arterial blood pressure and increases sperm motility. Subcellular Location: Secreted. Tissue Specificity: Expressed at low levels in the uterus of both pregnant and non-pregnant women. Isoform 1 is found only in the adrenal gland and fetal liver. Isoform 2 is found in heart, liver, bone marrow, prostate, adrenal gland and testis. Isoform 3 and isoform 4 are expressed predominantly in adrenal gland and placenta. Similarity: Belongs to the tachykinin family. SWISS: Q86UU9 Gene ID: 255061 Database links: Entrez Gene: 255061 Human Omim: 607833 Human SwissProt: Q86UU9 Human Unigene: 652130 Human

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