TEL: +86 571 56623320 EMAIL: [email protected]
Product Name LY6G6F Chinese Name lymphocyte抗原6重复位点蛋白G6F抗体 Alias C6orf21; Chromosome 6 open reading frame 21; G6F; G6f protein [Precursor]; HCG43720, isoform CRA_c; LY66F_HUMAN; LY6G6D; Ly6g6f; Lymphocyte antigen 6 complex locus G6F; Lymphocyte antigen 6 complex locus protein G6f; Lymphocyte antigen 6 complex, locus G6D; NG32. literatures Specific References (2) | SL20073R has been referenced in 2 publications.[IF=9.473] Li-Wei Liu. et al. Gut microbiota-derived nicotinamide mononucleotide alleviates acute pancreatitis by activating pancreatic SIRT3 signalling. BRIT J PHARMACOL. 2022 Nov;: IHC ; Rat, Mouse.[IF=6.832] Zhang, Yaqi. et al. MicroRNA-146a-5p-modified human umbilical cord mesenchymal stem cells enhance protection against diabetic nephropathy in rats through facilitating M2 macrophage polarization. STEM CELL RES THER. 2022 Dec;13(1):1-16 IHC ; Rat.Research Area Cell biology Signal transduction Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Mouse, Rat, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 32kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from rat LY6G6F: 101-200/293 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail lymphocyte antigen 6 complex locus protein G6f is a single-pass type I membrane protein belonging to the immunoglobulin (Ig) superfamily. Located in the class III region of the major histocompatibility complex (MHC), the G6f gene lies in a cluster of genes encoding cell-surface proteins that play a role in the immune system and cellular recognition. G6f functions as a downstream effector of GRB2 and GRB7, and, in humans, it interacts with GRB2 and GRB7 through the phosphorylation of a tyrosine residue (Tyr 281) in the intracellular tail of G6f. This interaction is also mediated by the SH2 domain of GRB2 and possibly that of GRB7. G6f is a 297 amino acid protein, and it forms a disulfide-linked homodimer.
Function:
May play a role in the downstream signal transduction pathways involving GRB2 and GRB7.
Subcellular Location:
Cell membrane.
Post-translational modifications:
modificationsN-glycosylated.
Similarity:
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
SWISS:
Q6MG56
Gene ID:
309609
Database links:Entrez Gene: 259215 Human
Entrez Gene: 433099 Mouse
Omim: 611404 Human
SwissProt: Q5SQ64 Human
SwissProt: Q7Z5H2 Human
Unigene: 591794 Human
Unigene: 145028 Rat
Scan Wechat Qrcode